Regular season and playoffs
| Year | Team | Games | Att | Cmp | Cmp% | Pass Yds | Pass TD | INT | Sacks | Y/A | Rating |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2005 | GB | 3 | 16 | 9 | 56.2 | 65 | 0 | 1 | 3 | 4.1 | 39.8 |
| 2006 | GB | 2 | 15 | 6 | 40.0 | 46 | 0 | 0 | 3 | 3.1 | 48.2 |
| 2007 | GB | 2 | 28 | 20 | 71.4 | 218 | 1 | 0 | 3 | 7.8 | 106.0 |
| 2008 | GB | 16 | 536 | 341 | 63.6 | 4038 | 28 | 13 | 34 | 7.5 | 93.8 |
| 2009 | GB | 17 | 583 | 378 | 64.8 | 4856 | 34 | 8 | 54 | 8.3 | 104.5 |
| 2010 | GB | 19 | 607 | 402 | 66.2 | 5016 | 37 | 13 | 39 | 8.3 | 103.1 |
| 2011 | GB | 16 | 547 | 368 | 67.3 | 4900 | 47 | 7 | 40 | 9.0 | 118.8 |
| 2012 | GB | 18 | 624 | 420 | 67.3 | 4826 | 42 | 9 | 55 | 7.7 | 106.8 |
| 2013 | GB | 10 | 316 | 210 | 66.5 | 2713 | 18 | 6 | 25 | 8.6 | 104.3 |
| 2014 | GB | 18 | 589 | 384 | 65.2 | 4875 | 42 | 7 | 31 | 8.3 | 109.7 |
| 2015 | GB | 18 | 652 | 392 | 60.1 | 4292 | 35 | 9 | 48 | 6.6 | 91.8 |
| 2016 | GB | 19 | 738 | 481 | 65.2 | 5432 | 49 | 9 | 45 | 7.4 | 104.1 |
| 2017 | GB | 7 | 238 | 154 | 64.7 | 1675 | 16 | 6 | 22 | 7.0 | 97.2 |
| 2018 | GB | 16 | 597 | 372 | 62.3 | 4442 | 25 | 2 | 49 | 7.4 | 97.6 |
| 2019 | GB | 18 | 635 | 400 | 63.0 | 4571 | 30 | 6 | 41 | 7.2 | 96.4 |
| 2020 | GB | 18 | 610 | 428 | 70.2 | 4941 | 53 | 6 | 25 | 8.1 | 119.2 |
| 2021 | GB | 17 | 560 | 386 | 68.9 | 4340 | 37 | 4 | 35 | 7.8 | 110.9 |
| 2022 | GB | 17 | 542 | 350 | 64.6 | 3695 | 26 | 12 | 32 | 6.8 | 91.1 |
| 2023 | NYJ | 1 | 1 | 0 | 0.0 | 0 | 0 | 0 | 1 | 0.0 | 39.6 |
| 2024 | NYJ | 17 | 584 | 368 | 63.0 | 3897 | 28 | 11 | 40 | 6.7 | 90.5 |
| 2025 | PIT | 17 | 531 | 344 | 64.8 | 3468 | 24 | 8 | 33 | 6.5 | 92.1 |
| 2026 | PIT | 7 | 263 | 162 | 61.6 | 1699 | 13 | 5 | 22 | 6.5 | 88.9 |