Regular season and playoffs
| Year | Team | Games | Att | Cmp | Cmp% | Pass Yds | Pass TD | INT | Sacks | Y/A | Rating |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2005 | SF | 9 | 165 | 84 | 50.9 | 875 | 1 | 11 | 29 | 5.3 | 40.8 |
| 2006 | SF | 16 | 443 | 259 | 58.5 | 2901 | 16 | 15 | 37 | 6.5 | 76.0 |
| 2007 | SF | 7 | 193 | 94 | 48.7 | 914 | 2 | 4 | 17 | 4.7 | 57.2 |
| 2009 | SF | 11 | 372 | 225 | 60.5 | 2350 | 18 | 12 | 22 | 6.3 | 81.5 |
| 2010 | SF | 11 | 342 | 204 | 59.6 | 2370 | 14 | 10 | 25 | 6.9 | 82.1 |
| 2011 | SF | 18 | 513 | 309 | 60.2 | 3639 | 22 | 5 | 51 | 7.1 | 92.1 |
| 2012 | SF | 10 | 218 | 153 | 70.2 | 1737 | 13 | 5 | 24 | 8.0 | 104.1 |
| 2013 | KC | 16 | 554 | 338 | 61.0 | 3691 | 27 | 7 | 41 | 6.7 | 91.7 |
| 2014 | KC | 15 | 464 | 303 | 65.3 | 3265 | 18 | 6 | 45 | 7.0 | 93.4 |
| 2015 | KC | 18 | 542 | 353 | 65.1 | 3922 | 22 | 8 | 49 | 7.2 | 93.9 |
| 2016 | KC | 16 | 523 | 348 | 66.5 | 3674 | 16 | 9 | 29 | 7.0 | 89.8 |
| 2017 | KC | 16 | 538 | 365 | 67.8 | 4306 | 28 | 5 | 39 | 8.0 | 105.4 |
| 2018 | WAS | 10 | 328 | 205 | 62.5 | 2180 | 10 | 5 | 22 | 6.6 | 85.7 |
| 2020 | WAS | 8 | 252 | 168 | 66.7 | 1582 | 6 | 8 | 22 | 6.3 | 78.5 |