Regular season and playoffs
| Year | Team | Games | Att | Cmp | Cmp% | Pass Yds | Pass TD | INT | Sacks | Y/A | Rating |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2012 | IND | 17 | 681 | 367 | 53.9 | 4662 | 23 | 19 | 44 | 6.8 | 75.1 |
| 2013 | IND | 18 | 656 | 392 | 59.8 | 4596 | 29 | 16 | 36 | 7.0 | 85.6 |
| 2014 | IND | 19 | 736 | 450 | 61.1 | 5528 | 43 | 20 | 28 | 7.5 | 92.5 |
| 2015 | IND | 7 | 293 | 162 | 55.3 | 1881 | 15 | 12 | 15 | 6.4 | 74.9 |
| 2016 | IND | 15 | 545 | 346 | 63.5 | 4240 | 31 | 13 | 41 | 7.8 | 96.4 |
| 2018 | IND | 18 | 707 | 468 | 66.2 | 5018 | 42 | 16 | 21 | 7.1 | 97.2 |