Regular season and playoffs
| Year | Team | Games | Att | Cmp | Cmp% | Pass Yds | Pass TD | INT | Sacks | Y/A | Rating |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2011 | CIN | 17 | 558 | 327 | 58.6 | 3655 | 20 | 16 | 28 | 6.6 | 78.2 |
| 2012 | CIN | 17 | 558 | 343 | 61.5 | 3796 | 27 | 17 | 48 | 6.8 | 85.1 |
| 2013 | CIN | 17 | 637 | 392 | 61.5 | 4627 | 34 | 22 | 32 | 7.3 | 87.0 |
| 2014 | CIN | 17 | 516 | 327 | 63.4 | 3553 | 19 | 17 | 24 | 6.9 | 82.1 |
| 2015 | CIN | 13 | 386 | 255 | 66.1 | 3250 | 25 | 7 | 20 | 8.4 | 106.2 |
| 2016 | CIN | 16 | 563 | 364 | 64.7 | 4206 | 18 | 8 | 41 | 7.5 | 91.8 |
| 2017 | CIN | 16 | 496 | 297 | 59.9 | 3320 | 25 | 12 | 39 | 6.7 | 86.6 |
| 2018 | CIN | 11 | 365 | 226 | 61.9 | 2566 | 21 | 11 | 21 | 7.0 | 89.6 |
| 2019 | CIN | 13 | 528 | 314 | 59.5 | 3494 | 16 | 14 | 37 | 6.6 | 78.3 |
| 2020 | DAL | 11 | 333 | 216 | 64.9 | 2170 | 14 | 8 | 24 | 6.5 | 87.3 |
| 2021 | CHI | 8 | 236 | 149 | 63.1 | 1515 | 8 | 9 | 18 | 6.4 | 76.9 |
| 2022 | NO | 14 | 378 | 252 | 66.7 | 2871 | 18 | 9 | 25 | 7.6 | 95.2 |
| 2023 | CAR | 2 | 58 | 34 | 58.6 | 361 | 2 | 0 | 3 | 6.2 | 88.4 |
| 2024 | CAR | 6 | 160 | 106 | 66.2 | 989 | 7 | 6 | 7 | 6.2 | 82.0 |
| 2025 | CAR | 4 | 37 | 25 | 67.6 | 293 | 1 | 1 | 8 | 7.9 | 89.1 |
| 2026 | PHI | 1 | 1 | 0 | 0.0 | 0 | 0 | 1 | 0 | 0.0 | 0.0 |