Regular season and playoffs
| Year | Team | Games | Att | Cmp | Cmp% | Pass Yds | Pass TD | INT | Sacks | Y/A | Rating |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2013 | HOU | 8 | 253 | 137 | 54.2 | 1760 | 9 | 6 | 19 | 7.0 | 78.2 |
| 2014 | HOU | 2 | 77 | 45 | 58.4 | 435 | 2 | 2 | 3 | 5.6 | 72.2 |
| 2015 | LA | 5 | 125 | 76 | 60.8 | 828 | 4 | 1 | 4 | 6.6 | 87.7 |
| 2016 | LA | 10 | 322 | 196 | 60.9 | 2201 | 9 | 11 | 23 | 6.8 | 76.4 |
| 2017 | MIN | 17 | 569 | 378 | 66.4 | 4136 | 24 | 10 | 25 | 7.3 | 94.5 |
| 2018 | DEN | 16 | 586 | 365 | 62.3 | 3890 | 18 | 15 | 34 | 6.6 | 81.2 |
| 2019 | WAS | 10 | 247 | 160 | 64.8 | 1707 | 11 | 5 | 15 | 6.9 | 91.3 |
| 2020 | CLE | 1 | 10 | 5 | 50.0 | 46 | 0 | 0 | 0 | 4.6 | 62.9 |
| 2021 | CLE | 5 | 72 | 47 | 65.3 | 462 | 3 | 1 | 5 | 6.4 | 91.3 |
| 2022 | BUF | 2 | 7 | 2 | 28.6 | 8 | 0 | 0 | 0 | 1.1 | 39.6 |
| 2023 | HOU | 2 | 53 | 34 | 64.2 | 291 | 1 | 3 | 6 | 5.5 | 61.1 |
| 2026 | CHI | 2 | 53 | 35 | 66.0 | 355 | 2 | 1 | 2 | 6.7 | 89.7 |