Regular season and playoffs
| Year | Team | Games | Att | Cmp | Cmp% | Pass Yds | Pass TD | INT | Sacks | Y/A | Rating |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2014 | LV | 16 | 599 | 348 | 58.1 | 3270 | 21 | 12 | 24 | 5.5 | 76.6 |
| 2015 | LV | 16 | 573 | 350 | 61.1 | 3987 | 32 | 13 | 31 | 7.0 | 91.1 |
| 2016 | LV | 15 | 560 | 357 | 63.7 | 3937 | 28 | 6 | 16 | 7.0 | 96.7 |
| 2017 | LV | 15 | 515 | 323 | 62.7 | 3496 | 22 | 13 | 20 | 6.8 | 86.4 |
| 2018 | LV | 16 | 553 | 381 | 68.9 | 4049 | 19 | 10 | 51 | 7.3 | 93.9 |
| 2019 | LV | 16 | 513 | 361 | 70.4 | 4054 | 21 | 8 | 29 | 7.9 | 100.8 |
| 2020 | LV | 16 | 517 | 348 | 67.3 | 4103 | 27 | 9 | 26 | 7.9 | 101.4 |
| 2021 | LV | 18 | 680 | 457 | 67.2 | 5114 | 24 | 15 | 43 | 7.5 | 92.0 |
| 2022 | LV | 15 | 502 | 305 | 60.8 | 3522 | 24 | 14 | 27 | 7.0 | 86.3 |
| 2023 | NO | 17 | 548 | 375 | 68.4 | 3878 | 25 | 8 | 31 | 7.1 | 97.7 |
| 2024 | NO | 10 | 279 | 189 | 67.7 | 2145 | 15 | 5 | 8 | 7.7 | 101.0 |