Regular season and playoffs
| Year | Team | Games | Att | Cmp | Cmp% | Pass Yds | Pass TD | INT | Sacks | Y/A | Rating |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2016 | NE | 3 | 55 | 34 | 61.8 | 400 | 0 | 0 | 6 | 7.3 | 83.9 |
| 2017 | IND | 16 | 469 | 276 | 58.8 | 3098 | 13 | 7 | 52 | 6.6 | 81.7 |
| 2018 | IND | 4 | 4 | 2 | 50.0 | 2 | 0 | 0 | 0 | 0.5 | 56.2 |
| 2019 | IND | 15 | 447 | 272 | 60.9 | 2942 | 18 | 6 | 27 | 6.6 | 88.0 |
| 2020 | IND | 12 | 8 | 2 | 25.0 | 17 | 0 | 0 | 2 | 2.1 | 39.6 |
| 2021 | MIA | 10 | 225 | 141 | 62.7 | 1283 | 5 | 4 | 19 | 5.7 | 78.1 |
| 2022 | CLE | 14 | 369 | 236 | 64.0 | 2608 | 12 | 6 | 24 | 7.1 | 88.9 |
| 2023 | WAS | 2 | 23 | 18 | 78.3 | 224 | 3 | 0 | 0 | 9.7 | 146.8 |
| 2024 | NE | 7 | 161 | 95 | 59.0 | 826 | 2 | 1 | 18 | 5.1 | 74.2 |
| 2025 | ARI | 14 | 485 | 315 | 64.9 | 3366 | 23 | 8 | 43 | 6.9 | 94.1 |
| 2026 | ARI | 7 | 282 | 183 | 64.9 | 1600 | 10 | 6 | 15 | 5.7 | 82.8 |