Regular season and playoffs
| Year | Team | Games | Att | Cmp | Cmp% | Pass Yds | Pass TD | INT | Sacks | Y/A | Rating |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2006 | DEN | 5 | 137 | 81 | 59.1 | 1001 | 9 | 5 | 13 | 7.3 | 88.5 |
| 2007 | DEN | 16 | 467 | 297 | 63.6 | 3497 | 20 | 14 | 27 | 7.5 | 88.1 |
| 2008 | DEN | 16 | 616 | 384 | 62.3 | 4525 | 25 | 18 | 11 | 7.3 | 86.0 |
| 2009 | CHI | 16 | 555 | 336 | 60.5 | 3666 | 27 | 26 | 34 | 6.6 | 76.8 |
| 2010 | CHI | 17 | 474 | 282 | 59.5 | 3628 | 25 | 17 | 57 | 7.7 | 86.2 |
| 2011 | CHI | 10 | 314 | 182 | 58.0 | 2319 | 13 | 7 | 23 | 7.4 | 85.7 |
| 2012 | CHI | 15 | 434 | 255 | 58.8 | 3033 | 19 | 14 | 38 | 7.0 | 81.3 |
| 2013 | CHI | 11 | 355 | 224 | 63.1 | 2621 | 19 | 12 | 19 | 7.4 | 89.2 |
| 2014 | CHI | 15 | 561 | 370 | 66.0 | 3812 | 28 | 18 | 38 | 6.8 | 88.6 |
| 2015 | CHI | 15 | 483 | 311 | 64.4 | 3659 | 21 | 11 | 29 | 7.6 | 92.3 |
| 2016 | CHI | 5 | 137 | 81 | 59.1 | 1059 | 4 | 5 | 17 | 7.7 | 78.1 |
| 2017 | MIA | 14 | 429 | 266 | 62.0 | 2666 | 19 | 14 | 20 | 6.2 | 80.8 |