Regular season and playoffs
| Year | Team | Games | Att | Cmp | Cmp% | Pass Yds | Pass TD | INT | Sacks | Y/A | Rating |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1986 | BUF | 16 | 480 | 285 | 59.4 | 3593 | 22 | 17 | 43 | 7.5 | 83.3 |
| 1987 | BUF | 12 | 419 | 250 | 59.7 | 2798 | 19 | 11 | 27 | 6.7 | 83.8 |
| 1988 | BUF | 18 | 515 | 302 | 58.6 | 3787 | 16 | 21 | 34 | 7.4 | 75.0 |
| 1989 | BUF | 14 | 445 | 256 | 57.5 | 3535 | 29 | 20 | 31 | 7.9 | 86.1 |
| 1990 | BUF | 17 | 428 | 273 | 63.8 | 3680 | 29 | 11 | 21 | 8.6 | 102.9 |
| 1991 | BUF | 18 | 592 | 368 | 62.2 | 4509 | 38 | 26 | 38 | 7.6 | 88.7 |
| 1992 | BUF | 18 | 493 | 290 | 58.8 | 3716 | 24 | 23 | 23 | 7.5 | 79.3 |
| 1993 | BUF | 19 | 584 | 363 | 62.2 | 4089 | 20 | 19 | 31 | 7.0 | 80.9 |
| 1994 | BUF | 14 | 448 | 285 | 63.6 | 3114 | 22 | 17 | 34 | 7.0 | 84.6 |
| 1995 | BUF | 17 | 509 | 281 | 55.2 | 3460 | 24 | 18 | 28 | 6.8 | 77.4 |
| 1996 | BUF | 14 | 411 | 243 | 59.1 | 3049 | 15 | 20 | 38 | 7.4 | 74.2 |