Regular season and playoffs
| Year | Team | Games | Att | Cmp | Cmp% | Pass Yds | Pass TD | INT | Sacks | Y/A | Rating |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2008 | BAL | 19 | 503 | 290 | 57.7 | 3408 | 15 | 15 | 36 | 6.8 | 75.9 |
| 2009 | BAL | 18 | 544 | 339 | 62.3 | 3836 | 21 | 15 | 38 | 7.1 | 84.8 |
| 2010 | BAL | 18 | 553 | 347 | 62.7 | 4012 | 28 | 11 | 49 | 7.3 | 93.2 |
| 2011 | BAL | 18 | 605 | 348 | 57.5 | 4092 | 24 | 13 | 39 | 6.8 | 82.5 |
| 2012 | BAL | 20 | 657 | 390 | 59.4 | 4957 | 33 | 10 | 41 | 7.5 | 93.4 |
| 2013 | BAL | 16 | 614 | 362 | 59.0 | 3912 | 19 | 22 | 48 | 6.4 | 73.1 |
| 2014 | BAL | 18 | 628 | 390 | 62.1 | 4537 | 33 | 14 | 20 | 7.2 | 92.2 |
| 2015 | BAL | 10 | 413 | 266 | 64.4 | 2791 | 14 | 12 | 16 | 6.8 | 83.1 |
| 2016 | BAL | 16 | 672 | 436 | 64.9 | 4317 | 20 | 15 | 33 | 6.4 | 83.5 |
| 2017 | BAL | 16 | 549 | 352 | 64.1 | 3141 | 18 | 13 | 27 | 5.7 | 80.4 |
| 2018 | BAL | 9 | 379 | 232 | 61.2 | 2465 | 12 | 6 | 16 | 6.5 | 84.2 |
| 2019 | DEN | 8 | 262 | 171 | 65.3 | 1822 | 6 | 5 | 26 | 7.0 | 85.1 |
| 2020 | NYJ | 5 | 134 | 74 | 55.2 | 864 | 6 | 3 | 7 | 6.4 | 80.6 |
| 2021 | NYJ | 2 | 42 | 27 | 64.3 | 338 | 3 | 0 | 2 | 8.0 | 113.0 |
| 2022 | NYJ | 5 | 191 | 110 | 57.6 | 1051 | 5 | 3 | 10 | 5.5 | 75.2 |
| 2023 | CLE | 6 | 250 | 157 | 62.8 | 1923 | 14 | 10 | 12 | 7.7 | 88.5 |
| 2024 | IND | 7 | 248 | 162 | 65.3 | 1761 | 12 | 7 | 18 | 7.1 | 90.5 |
| 2025 | CIN | 13 | 416 | 251 | 60.3 | 2479 | 15 | 10 | 18 | 6.0 | 79.2 |