Regular season and playoffs
| Year | Team | Games | Att | Cmp | Cmp% | Pass Yds | Pass TD | INT | Sacks | Y/A | Rating |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2015 | TEN | 12 | 370 | 230 | 62.2 | 2818 | 19 | 10 | 38 | 7.6 | 91.5 |
| 2016 | TEN | 15 | 451 | 276 | 61.2 | 3426 | 26 | 9 | 23 | 7.6 | 95.6 |
| 2017 | TEN | 17 | 522 | 323 | 61.9 | 3701 | 17 | 16 | 37 | 7.1 | 81.3 |
| 2018 | TEN | 14 | 331 | 228 | 68.9 | 2528 | 11 | 8 | 42 | 7.6 | 92.3 |
| 2019 | TEN | 9 | 161 | 96 | 59.6 | 1207 | 7 | 2 | 25 | 7.5 | 92.3 |
| 2020 | LV | 1 | 28 | 17 | 60.7 | 226 | 1 | 1 | 0 | 8.1 | 83.3 |
| 2021 | LV | 7 | 2 | 1 | 50.0 | 4 | 0 | 0 | 0 | 2.0 | 56.2 |
| 2022 | ATL | 13 | 300 | 184 | 61.3 | 2219 | 15 | 9 | 28 | 7.4 | 88.2 |
| 2023 | PHI | 2 | 23 | 15 | 65.2 | 164 | 1 | 1 | 3 | 7.1 | 82.5 |
| 2024 | WAS | 5 | 44 | 34 | 77.3 | 364 | 4 | 0 | 3 | 8.3 | 131.2 |
| 2025 | WAS | 10 | 227 | 139 | 61.2 | 1695 | 10 | 7 | 16 | 7.5 | 86.1 |
| 2026 | WAS | 3 | 51 | 33 | 64.7 | 340 | 4 | 0 | 3 | 6.7 | 109.9 |