Regular season and playoffs
| Year | Team | Games | Att | Cmp | Cmp% | Pass Yds | Pass TD | INT | Sacks | Y/A | Rating |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2008 | ATL | 17 | 474 | 291 | 61.4 | 3639 | 18 | 13 | 20 | 7.7 | 86.5 |
| 2009 | ATL | 14 | 451 | 263 | 58.3 | 2916 | 22 | 14 | 19 | 6.5 | 80.9 |
| 2010 | ATL | 17 | 600 | 377 | 62.8 | 3891 | 29 | 11 | 28 | 6.5 | 89.9 |
| 2011 | ATL | 17 | 607 | 371 | 61.1 | 4376 | 29 | 12 | 28 | 7.2 | 90.7 |
| 2012 | ATL | 18 | 692 | 476 | 68.8 | 5365 | 38 | 17 | 29 | 7.8 | 99.8 |
| 2013 | ATL | 16 | 651 | 439 | 67.4 | 4515 | 26 | 17 | 44 | 6.9 | 89.6 |
| 2014 | ATL | 16 | 628 | 415 | 66.1 | 4694 | 28 | 14 | 31 | 7.5 | 93.9 |
| 2015 | ATL | 16 | 614 | 407 | 66.3 | 4591 | 21 | 16 | 30 | 7.5 | 89.0 |
| 2016 | ATL | 19 | 632 | 443 | 70.1 | 5958 | 47 | 7 | 45 | 9.4 | 119.9 |
| 2017 | ATL | 18 | 595 | 385 | 64.7 | 4523 | 22 | 12 | 30 | 7.6 | 91.6 |
| 2018 | ATL | 16 | 608 | 422 | 69.4 | 4924 | 35 | 7 | 42 | 8.1 | 108.1 |
| 2019 | ATL | 15 | 616 | 408 | 66.2 | 4466 | 26 | 14 | 48 | 7.2 | 92.1 |
| 2020 | ATL | 16 | 626 | 407 | 65.0 | 4581 | 26 | 11 | 41 | 7.3 | 93.3 |
| 2021 | ATL | 17 | 560 | 375 | 67.0 | 3968 | 20 | 12 | 40 | 7.1 | 90.4 |
| 2022 | IND | 12 | 461 | 309 | 67.0 | 3057 | 14 | 13 | 38 | 6.6 | 83.9 |