Regular season and playoffs
| Year | Team | Games | Att | Cmp | Cmp% | Pass Yds | Pass TD | INT | Sacks | Y/A | Rating |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2004 | ATL | 6 | 70 | 33 | 47.1 | 329 | 1 | 4 | 4 | 4.7 | 41.9 |
| 2005 | ATL | 7 | 64 | 33 | 51.6 | 495 | 4 | 0 | 6 | 7.7 | 98.1 |
| 2006 | ATL | 7 | 27 | 18 | 66.7 | 208 | 1 | 2 | 2 | 7.7 | 71.2 |
| 2007 | HOU | 11 | 289 | 192 | 66.4 | 2241 | 9 | 9 | 16 | 7.8 | 87.2 |
| 2008 | HOU | 11 | 380 | 251 | 66.1 | 3043 | 15 | 10 | 23 | 8.0 | 92.7 |
| 2009 | HOU | 16 | 583 | 396 | 67.9 | 4770 | 29 | 15 | 26 | 8.2 | 98.6 |
| 2010 | HOU | 16 | 574 | 365 | 63.6 | 4370 | 24 | 12 | 32 | 7.6 | 92.0 |
| 2011 | HOU | 10 | 292 | 178 | 61.0 | 2479 | 15 | 6 | 16 | 8.5 | 96.8 |
| 2012 | HOU | 18 | 633 | 413 | 65.2 | 4613 | 24 | 14 | 28 | 7.3 | 90.2 |
| 2013 | HOU | 10 | 358 | 219 | 61.2 | 2310 | 10 | 14 | 21 | 6.5 | 73.0 |
| 2014 | LV | 2 | 10 | 5 | 50.0 | 57 | 0 | 2 | 3 | 5.7 | 27.9 |
| 2015 | BAL | 2 | 80 | 52 | 65.0 | 540 | 3 | 4 | 3 | 6.8 | 76.0 |
| 2016 | ATL | 3 | 3 | 1 | 33.3 | 16 | 0 | 0 | 0 | 5.3 | 52.1 |
| 2018 | ATL | 2 | 7 | 5 | 71.4 | 20 | 0 | 0 | 0 | 2.9 | 74.1 |
| 2019 | ATL | 5 | 67 | 50 | 74.6 | 580 | 3 | 1 | 2 | 8.7 | 109.0 |