Regular season and playoffs
| Year | Team | Games | Att | Cmp | Cmp% | Pass Yds | Pass TD | INT | Sacks | Y/A | Rating |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2017 | KC | 1 | 35 | 22 | 62.9 | 284 | 0 | 1 | 2 | 8.1 | 76.4 |
| 2018 | KC | 18 | 652 | 426 | 65.3 | 5670 | 53 | 12 | 34 | 8.7 | 112.2 |
| 2019 | KC | 17 | 596 | 391 | 65.6 | 4932 | 36 | 7 | 23 | 8.3 | 106.5 |
| 2020 | KC | 18 | 705 | 466 | 66.1 | 5590 | 42 | 8 | 26 | 7.9 | 105.3 |
| 2021 | KC | 20 | 780 | 525 | 67.3 | 5896 | 48 | 16 | 37 | 7.6 | 101.6 |
| 2022 | KC | 20 | 748 | 507 | 67.8 | 5953 | 48 | 12 | 29 | 8.0 | 106.4 |
| 2023 | KC | 20 | 746 | 505 | 67.7 | 5234 | 33 | 15 | 32 | 7.0 | 94.1 |
| 2024 | KC | 19 | 664 | 447 | 67.3 | 4607 | 31 | 13 | 47 | 6.9 | 94.5 |
| 2025 | KC | 14 | 502 | 315 | 62.7 | 3587 | 22 | 11 | 34 | 7.1 | 89.6 |
| 2026 | KC | 6 | 191 | 124 | 64.9 | 1474 | 9 | 4 | 7 | 7.7 | 95.3 |