Regular season and playoffs
| Year | Team | Games | Att | Cmp | Cmp% | Pass Yds | Pass TD | INT | Sacks | Y/A | Rating |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2000 | NE | 1 | 3 | 1 | 33.3 | 6 | 0 | 0 | 0 | 2.0 | 42.4 |
| 2001 | NE | 18 | 510 | 324 | 63.5 | 3415 | 19 | 13 | 46 | 6.7 | 84.7 |
| 2002 | NE | 16 | 601 | 373 | 62.1 | 3764 | 28 | 14 | 31 | 6.3 | 85.7 |
| 2003 | NE | 19 | 654 | 392 | 59.9 | 4412 | 28 | 14 | 32 | 6.7 | 85.5 |
| 2004 | NE | 19 | 555 | 343 | 61.8 | 4277 | 33 | 14 | 33 | 7.7 | 95.0 |
| 2005 | NE | 18 | 593 | 369 | 62.2 | 4652 | 30 | 16 | 30 | 7.8 | 92.2 |
| 2006 | NE | 19 | 636 | 390 | 61.3 | 4257 | 29 | 16 | 30 | 6.7 | 85.8 |
| 2007 | NE | 19 | 687 | 475 | 69.1 | 5543 | 56 | 11 | 29 | 8.1 | 113.8 |
| 2008 | NE | 1 | 11 | 7 | 63.6 | 76 | 0 | 0 | 0 | 6.9 | 83.9 |
| 2009 | NE | 17 | 607 | 394 | 64.9 | 4552 | 30 | 16 | 19 | 7.5 | 92.9 |
| 2010 | NE | 17 | 537 | 353 | 65.7 | 4199 | 38 | 5 | 30 | 7.8 | 109.2 |
| 2011 | NE | 19 | 722 | 476 | 65.9 | 6113 | 47 | 16 | 35 | 8.5 | 104.8 |
| 2012 | NE | 18 | 731 | 455 | 62.2 | 5491 | 38 | 10 | 28 | 7.5 | 96.9 |
| 2013 | NE | 18 | 691 | 417 | 60.3 | 4818 | 26 | 11 | 44 | 7.0 | 87.3 |
| 2014 | NE | 19 | 717 | 466 | 65.0 | 5030 | 43 | 13 | 25 | 7.0 | 97.9 |
| 2015 | NE | 18 | 722 | 457 | 63.3 | 5382 | 39 | 9 | 42 | 7.5 | 98.7 |
| 2016 | NE | 15 | 574 | 384 | 66.9 | 4691 | 35 | 5 | 24 | 8.2 | 108.6 |
| 2017 | NE | 19 | 720 | 474 | 65.8 | 5709 | 40 | 8 | 39 | 7.9 | 103.9 |
| 2018 | NE | 19 | 695 | 460 | 66.2 | 5308 | 31 | 14 | 22 | 7.6 | 95.5 |
| 2019 | NE | 17 | 650 | 393 | 60.5 | 4266 | 24 | 9 | 27 | 6.6 | 86.4 |
| 2020 | TB | 20 | 748 | 482 | 64.4 | 5694 | 50 | 15 | 27 | 7.6 | 101.4 |
| 2021 | TB | 19 | 810 | 544 | 67.2 | 5916 | 46 | 13 | 29 | 7.3 | 100.7 |
| 2022 | TB | 18 | 799 | 525 | 65.7 | 5045 | 27 | 10 | 24 | 6.3 | 89.2 |