Franchise 77 seasons 465–656–19 all-time 9 playoff trips 0 Super Bowls
2021 players
Passing
| Kyler Murray | 481 | 333 | 3,787 | 24 | 10 | 7.9 |
| Colt McCoy | 99 | 74 | 740 | 3 | 1 | 7.5 |
| Chris Streveler | 9 | 6 | 36 | 0 | 0 | 4.0 |
| Christian Kirk | 1 | 1 | 33 | 0 | 0 | 33.0 |
| Chris Banjo | 1 | 1 | 23 | 0 | 0 | 23.0 |
Rushing
| James Conner | 202 | 752 | 15 | 3.7 |
| Chase Edmonds | 116 | 592 | 2 | 5.1 |
| Kyler Murray | 88 | 423 | 5 | 4.8 |
| Eno Benjamin | 34 | 118 | 1 | 3.5 |
| Rondale Moore | 18 | 76 | 0 | 4.2 |
| Colt McCoy | 22 | 37 | 0 | 1.7 |
| Jonathan Ward | 9 | 33 | 0 | 3.7 |
| Greg Dortch | 1 | 24 | 0 | 24.0 |
| Christian Kirk | 1 | 11 | 0 | 11.0 |
| Chris Streveler | 3 | 6 | 0 | 2.0 |
| Zach Ertz | 1 | 4 | 0 | 4.0 |
| Andy Lee | 1 | 0 | 0 | 0.0 |
Receiving
| Christian Kirk | 103 | 77 | 982 | 5 | 9.5 |
| A.J. Green | 92 | 54 | 848 | 3 | 9.2 |
| Zach Ertz | 112 | 74 | 763 | 5 | 6.8 |
| DeAndre Hopkins | 64 | 42 | 572 | 8 | 8.9 |
| Rondale Moore | 64 | 54 | 435 | 1 | 6.8 |
| James Conner | 39 | 37 | 375 | 3 | 9.6 |
| Chase Edmonds | 53 | 43 | 311 | 0 | 5.9 |
| Antoine Wesley | 32 | 19 | 208 | 3 | 6.5 |
| Maxx Williams | 17 | 16 | 193 | 1 | 11.4 |
| Eno Benjamin | 7 | 6 | 42 | 0 | 6.0 |
| Jonathan Ward | 4 | 3 | 34 | 0 | 8.5 |
| Greg Dortch | 3 | 3 | 15 | 0 | 5.0 |
| Andy Isabella | 1 | 1 | 13 | 0 | 13.0 |
| Demetrius Harris | 6 | 3 | 10 | 0 | 1.7 |
| Darrell Daniels | 4 | 1 | 0 | 0 | 0.0 |
Defense
| Jalen Thompson | SAF | 112 | 70 | 0.0 | 3 | 7 | 0 |
| Jordan Hicks | MLB | 103 | 62 | 4.0 | 0 | 5 | 1 |
| Isaiah Simmons | LB | 100 | 65 | 1.5 | 1 | 7 | 4 |
| Budda Baker | S | 95 | 60 | 2.0 | 3 | 7 | 0 |
| Byron Murphy | CB | 64 | 49 | 0.5 | 4 | 12 | 1 |
| Marco Wilson | CB | 44 | 36 | 0.0 | 0 | 4 | 2 |
| Markus Golden | LB | 44 | 29 | 11.0 | 0 | 1 | 4 |
| Zach Allen | DE | 42 | 24 | 4.0 | 1 | 4 | 0 |
| Chandler Jones | DE | 38 | 28 | 10.5 | 0 | 4 | 6 |
| Antonio Hamilton | CB | 36 | 29 | 0.0 | 0 | 4 | 0 |
| Robert Alford | CB | 36 | 29 | 0.0 | 1 | 4 | 0 |
| Michael Dogbe | DE | 25 | 12 | 1.0 | 0 | 0 | 0 |
| Dennis Gardeck | LB | 23 | 14 | 0.0 | 0 | 0 | 0 |
| Zaven Collins | LB | 23 | 11 | 0.0 | 0 | 3 | 0 |
| Corey Peters | DE | 22 | 8 | 0.0 | 0 | 1 | 0 |
| Devon Kennard | OLB | 21 | 12 | 0.0 | 0 | 2 | 0 |
| Jordan Phillips | DT | 20 | 12 | 3.0 | 0 | 2 | 0 |
| Leki Fotu | DT | 17 | 6 | 0.0 | 0 | 3 | 1 |
| J.J. Watt | DE | 12 | 6 | 1.0 | 0 | 2 | 1 |
| Rashard Lawrence | DT | 11 | 6 | 0.0 | 0 | 0 | 0 |
| Tanner Vallejo | ILB | 9 | 5 | 0.5 | 0 | 1 | 0 |
| Joe Walker | LB | 9 | 4 | 0.0 | 0 | 0 | 0 |
| Breon Borders | CB | 8 | 7 | 0.0 | 0 | 2 | 0 |
| Deionte Thompson | SAF | 7 | 4 | 0.0 | 0 | 0 | 0 |
| Kevin Peterson | CB | 7 | 5 | 0.0 | 0 | 0 | 0 |
| Demetrius Harris | TE | 6 | 4 | 0.0 | 0 | 0 | 0 |
| Chris Banjo | DB | 6 | 3 | 0.0 | 0 | 0 | 0 |
| Darrell Daniels | TE | 6 | 3 | 0.0 | 0 | 0 | 0 |
| Zach Kerr | DE | 6 | 2 | 0.0 | 0 | 0 | 0 |
| Jonathan Ward | RB | 5 | 3 | 0.0 | 0 | 0 | 1 |
| Ezekiel Turner | LB | 4 | 3 | 0.0 | 0 | 0 | 0 |
| Josh Mauro | DE | 3 | 1 | 1.0 | 0 | 0 | 0 |
| Charles Washington | DB | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Jace Whittaker | CB | 3 | 2 | 0.0 | 0 | 0 | 0 |
| Victor Dimukeje | LB | 3 | 0 | 0.0 | 0 | 0 | 0 |
| Andy Isabella | WR | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Chase Edmonds | RB | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Rodney Hudson | C | 1 | 1 | 0.0 | 0 | 0 | 0 |
| A.J. Green | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Colt McCoy | QB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Tahir Whitehead | OLB | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Maxx Williams | TE | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Justin Pugh | G | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Justin Murray | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Kylie Fitts | LB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| James Conner | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Greg Dortch | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Eno Benjamin | RB | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Rondale Moore | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |