Franchise 77 seasons 465–656–19 all-time 9 playoff trips 0 Super Bowls
2022 players
Passing
| Kyler Murray | 390 | 259 | 2,368 | 14 | 7 | 6.1 |
| Colt McCoy | 132 | 90 | 780 | 1 | 3 | 5.9 |
| Trace McSorley | 83 | 45 | 412 | 0 | 5 | 5.0 |
| David Blough | 58 | 38 | 402 | 2 | 2 | 6.9 |
| Andy Lee | 1 | 1 | 4 | 0 | 0 | 4.0 |
Rushing
| James Conner | 183 | 782 | 7 | 4.3 |
| Kyler Murray | 67 | 418 | 3 | 6.2 |
| Darrel Williams | 21 | 102 | 1 | 4.9 |
| Trace McSorley | 15 | 61 | 0 | 4.1 |
| Keaontay Ingram | 27 | 60 | 1 | 2.2 |
| Corey Clement | 15 | 55 | 1 | 3.7 |
| Greg Dortch | 7 | 44 | 0 | 6.3 |
| Colt McCoy | 14 | 36 | 0 | 2.6 |
| Pharoh Cooper | 4 | 15 | 0 | 3.8 |
| David Blough | 4 | 5 | 0 | 1.2 |
| Marquise Brown | 1 | 1 | 0 | 1.0 |
| Rondale Moore | 6 | -5 | 0 | -0.8 |
Receiving
| DeAndre Hopkins | 96 | 64 | 717 | 3 | 7.5 |
| Marquise Brown | 107 | 67 | 709 | 3 | 6.6 |
| Greg Dortch | 64 | 52 | 467 | 2 | 7.3 |
| Rondale Moore | 56 | 41 | 414 | 1 | 7.4 |
| Zach Ertz | 69 | 47 | 406 | 4 | 5.9 |
| James Conner | 58 | 46 | 300 | 1 | 5.2 |
| Robbie Chosen | 44 | 20 | 282 | 1 | 6.4 |
| Trey McBride | 39 | 29 | 265 | 1 | 6.8 |
| A.J. Green | 47 | 24 | 236 | 2 | 5.0 |
| Corey Clement | 7 | 5 | 54 | 0 | 7.7 |
| Andre Baccellia | 10 | 7 | 45 | 0 | 4.5 |
| Keaontay Ingram | 5 | 4 | 21 | 0 | 4.2 |
| Maxx Williams | 3 | 3 | 18 | 0 | 6.0 |
| Stephen Anderson | 7 | 3 | 9 | 0 | 1.3 |
| Darrel Williams | 8 | 4 | 9 | 0 | 1.1 |
| Pharoh Cooper | 2 | 2 | 6 | 0 | 3.0 |
| Ty'Son Williams | 1 | 1 | 5 | 0 | 5.0 |
| Kamu Grugier-Hill | 1 | 1 | 4 | 0 | 4.0 |