Franchise 77 seasons 563–571–9 all-time 20 playoff trips 1 Super Bowls
1991 players
Passing
| Jim Harbaugh | 478 | 275 | 3,121 | 15 | 16 | 6.5 |
| Peter Tom Willis | 18 | 11 | 171 | 1 | 1 | 9.5 |
| Neal Anderson | 1 | 0 | 0 | 0 | 0 | 0.0 |
Rushing
| Neal Anderson | 210 | 747 | 6 | 3.6 |
| Brad Muster | 90 | 412 | 6 | 4.6 |
| Jim Harbaugh | 70 | 338 | 2 | 4.8 |
| Mark Green | 61 | 217 | 3 | 3.6 |
| James Rouse | 27 | 74 | 0 | 2.7 |
| Dennis Gentry | 9 | 58 | 0 | 6.4 |
| Johnny Bailey | 15 | 43 | 1 | 2.9 |
| Darren Lewis | 15 | 36 | 0 | 2.4 |
| Anthony Morgan | 3 | 18 | 0 | 6.0 |
| Peter Tom Willis | 2 | 6 | 0 | 3.0 |
Receiving
| Wendell Davis | 108 | 61 | 945 | 6 | 8.8 |
| Tom Waddle | 88 | 55 | 599 | 3 | 6.8 |
| Neal Anderson | 66 | 47 | 368 | 3 | 5.6 |
| Brad Muster | 45 | 35 | 287 | 1 | 6.4 |
| James Thornton | 39 | 17 | 278 | 1 | 7.1 |
| Anthony Morgan | 31 | 13 | 211 | 2 | 6.8 |
| Dennis Gentry | 30 | 16 | 149 | 0 | 5.0 |
| Ron Morris | 17 | 8 | 147 | 0 | 8.6 |
| Keith Jennings | 11 | 8 | 109 | 0 | 9.9 |
| James Rouse | 21 | 15 | 93 | 0 | 4.4 |
| Mark Green | 13 | 6 | 54 | 0 | 4.2 |
| Cap Boso | 7 | 3 | 36 | 0 | 5.1 |
| Glen Kozlowski | 3 | 2 | 16 | 0 | 5.3 |
Defense
| Steve McMichael | LDT | 94 | 94 | 9.0 | 0 | 2 |
| Mark Carrier | FS | 93 | 93 | 0.0 | 2 | 2 |
| Richard Dent | RDE | 84 | 84 | 10.5 | 1 | 1 |
| William Perry | RDT | 80 | 80 | 5.5 | 0 | 2 |
| Donnell Woolford | LCB | 77 | 77 | 1.0 | 2 | 0 |
| John Mangum | DB | 68 | 68 | 1.0 | 1 | 1 |
| Shaun Gayle | SS | 67 | 67 | 0.0 | 1 | 1 |
| Trace Armstrong | LDE | 56 | 56 | 1.5 | 0 | 0 |
| David Tate | DB | 30 | 30 | 0.0 | 2 | 0 |
| Dante Jones | LB | 28 | 28 | 0.0 | 0 | 0 |
| Maurice Douglass | DB | 17 | 17 | 0.0 | 0 | 0 |
| Chris Zorich | DT | 10 | 10 | 0.0 | 0 | 0 |
| Mike Stonebreaker | LB | 8 | 8 | 0.0 | 0 | 0 |
| Ron Cox | LB | 6 | 6 | 1.0 | 0 | 1 |
| John Roper | RLB | 0 | 0 | 8.0 | 0 | 0 |
| James Williams | DE | 0 | 0 | 1.0 | 0 | 0 |
| Tim Ryan | DT | 0 | 0 | 1.5 | 0 | 1 |