Franchise 77 seasons 563–571–9 all-time 20 playoff trips 1 Super Bowls
1992 players
Passing
| Jim Harbaugh | 358 | 202 | 2,486 | 13 | 12 | 6.9 |
| Peter Tom Willis | 92 | 54 | 716 | 4 | 8 | 7.8 |
| Will Furrer | 25 | 9 | 89 | 0 | 3 | 3.6 |
| Chris Gardocki | 3 | 1 | 43 | 0 | 0 | 14.3 |
| Brad Muster | 1 | 0 | 0 | 0 | 1 | 0.0 |
Rushing
| Neal Anderson | 156 | 582 | 5 | 3.7 |
| Brad Muster | 98 | 414 | 3 | 4.2 |
| Darren Lewis | 90 | 382 | 4 | 4.2 |
| Jim Harbaugh | 47 | 272 | 1 | 5.8 |
| Mark Green | 23 | 107 | 2 | 4.7 |
| Anthony Morgan | 3 | 68 | 0 | 22.7 |
| Wendell Davis | 4 | 42 | 0 | 10.5 |
| Dennis Gentry | 5 | 2 | 0 | 0.4 |
| Peter Tom Willis | 1 | 2 | 0 | 2.0 |
Receiving
| Wendell Davis | 110 | 54 | 734 | 2 | 6.7 |
| Tom Waddle | 80 | 46 | 674 | 4 | 8.4 |
| Neal Anderson | 65 | 42 | 399 | 6 | 6.1 |
| Brad Muster | 44 | 34 | 389 | 2 | 8.8 |
| Anthony Morgan | 32 | 14 | 323 | 2 | 10.1 |
| Keith Jennings | 33 | 23 | 264 | 1 | 8.0 |
| Darren Lewis | 27 | 18 | 175 | 0 | 6.5 |
| Dennis Gentry | 30 | 12 | 114 | 0 | 3.8 |
| Mark Green | 10 | 7 | 85 | 0 | 8.5 |
| Eric Wright | 8 | 5 | 56 | 0 | 7.0 |
| Kelly Blackwell | 13 | 5 | 54 | 0 | 4.2 |
| Ron Morris | 10 | 4 | 44 | 0 | 4.4 |
| Barry Wagner | 1 | 1 | 16 | 0 | 16.0 |
| Glen Kozlowski | 3 | 1 | 7 | 0 | 2.3 |
Defense
| Shaun Gayle | SS | 100 | 100 | 0.0 | 2 | 0 |
| Donnell Woolford | LCB | 94 | 94 | 0.0 | 7 | 1 |
| Mark Carrier | FS | 89 | 89 | 0.0 | 0 | 1 |
| Steve McMichael | LDT | 89 | 89 | 10.5 | 0 | 4 |
| Richard Dent | RDE | 82 | 82 | 8.5 | 0 | 4 |
| Trace Armstrong | LDE | 75 | 75 | 6.5 | 0 | 1 |
| Ron Cox | LB | 56 | 56 | 1.0 | 0 | 2 |
| Chris Zorich | DT | 53 | 53 | 2.0 | 0 | 0 |
| David Tate | DB | 49 | 49 | 0.0 | 0 | 0 |
| William Perry | RDT | 48 | 48 | 2.0 | 0 | 2 |
| Alonzo Spellman | DE | 30 | 30 | 4.0 | 0 | 0 |
| Dante Jones | LB | 29 | 29 | 0.0 | 0 | 0 |
| John Mangum | DB | 10 | 10 | 0.0 | 0 | 0 |
| Maurice Douglass | DB | 3 | 3 | 0.0 | 0 | 0 |
| Jim Morrissey | RLB | 0 | 0 | 1.0 | 1 | 0 |
| Mike Singletary | MLB | 0 | 0 | 1.0 | 1 | 1 |
| John Roper | LLB | 0 | 0 | 2.5 | 0 | 0 |
| Ron Rivera | LB | 0 | 0 | 1.0 | 0 | 0 |
| Tim Ryan | DT | 0 | 0 | 3.0 | 0 | 0 |