Franchise 74 seasons 523–560–11 all-time 26 playoff trips 0 Super Bowls
2004 players
Passing
| Jeff Garcia | 252 | 144 | 1,731 | 10 | 9 | 6.9 |
| Kelly Holcomb | 87 | 59 | 737 | 7 | 5 | 8.5 |
| Luke McCown | 98 | 48 | 608 | 4 | 7 | 6.2 |
| Frisman Jackson | 1 | 0 | 0 | 0 | 0 | 0.0 |
| Adimchinobe Echemandu | 1 | 0 | 0 | 0 | 0 | 0.0 |
Rushing
| Lee Suggs | 199 | 744 | 2 | 3.7 |
| William Green | 163 | 585 | 2 | 3.6 |
| Jeff Garcia | 34 | 169 | 2 | 5.0 |
| Luke McCown | 5 | 25 | 0 | 5.0 |
| Adimchinobe Echemandu | 8 | 25 | 0 | 3.1 |
| Dennis Northcutt | 8 | 19 | 0 | 2.4 |
| Terrelle Smith | 4 | 9 | 0 | 2.2 |
| Frisman Jackson | 1 | 4 | 0 | 4.0 |
| Derrick Frost | 1 | 1 | 0 | 1.0 |
| Kelly Holcomb | 3 | -2 | 0 | -0.7 |
| Andre Davis | 1 | -3 | 0 | -3.0 |
Receiving
| Antonio Bryant | 58 | 812 | 4 | 14.0 |
| Dennis Northcutt | 55 | 806 | 2 | 14.7 |
| Andre Davis | 16 | 416 | 2 | 26.0 |
| Steve Heiden | 28 | 287 | 5 | 10.2 |
| Aaron Shea | 26 | 252 | 4 | 9.7 |
| Lee Suggs | 20 | 178 | 1 | 8.9 |
| Frisman Jackson | 13 | 168 | 0 | 12.9 |
| William Green | 14 | 84 | 0 | 6.0 |
| Kellen Winslow | 5 | 50 | 0 | 10.0 |
| Andre King | 5 | 49 | 0 | 9.8 |
| Terrelle Smith | 7 | 39 | 0 | 5.6 |
| Adimchinobe Echemandu | 3 | 25 | 0 | 8.3 |
| Chad Mustard | 1 | 9 | 0 | 9.0 |
| Keith Heinrich | 1 | 1 | 0 | 1.0 |
Defense
| Robert Griffith | FS | 97 | 70 | 1.0 | 1 | 3 | 0 |
| Anthony Henry | CB | 69 | 60 | 0.0 | 4 | 12 | 0 |
| Warrick Holdman | LB | 61 | 33 | 0.0 | 0 | 2 | 0 |
| Kevin Bentley | LB | 56 | 37 | 0.0 | 0 | 0 | 1 |
| Andra Davis | ILB | 54 | 37 | 1.0 | 3 | 6 | 0 |
| Kenard Lang | DE | 50 | 37 | 7.0 | 0 | 4 | 2 |
| Chaun Thompson | LB | 49 | 28 | 3.0 | 0 | 3 | 0 |
| Chris Crocker | DB | 47 | 37 | 2.0 | 1 | 4 | 0 |
| Earl Little | DB | 45 | 33 | 0.0 | 1 | 5 | 1 |
| Daylon McCutcheon | DB | 43 | 38 | 0.0 | 2 | 9 | 0 |
| Alvin McKinley | DT | 37 | 17 | 3.0 | 0 | 1 | 0 |
| Barry Gardner | LB | 31 | 16 | 0.0 | 1 | 2 | 0 |
| Ebenezer Ekuban | DE | 30 | 20 | 8.0 | 0 | 2 | 1 |
| Michael Myers | DT | 30 | 18 | 1.0 | 0 | 0 | 1 |
| Orpheus Roye | DE | 29 | 21 | 1.0 | 0 | 5 | 0 |
| Lewis Sanders | DB | 25 | 18 | 0.0 | 2 | 6 | 0 |
| Eric Westmoreland | LB | 20 | 14 | 0.0 | 0 | 1 | 1 |
| Leigh Bodden | DB | 18 | 16 | 0.0 | 0 | 0 | 1 |
| Tyrone Rogers | LB | 17 | 12 | 1.0 | 0 | 1 | 0 |
| Mason Unck | LB | 16 | 14 | 0.0 | 0 | 0 | 0 |
| Michael Jameson | CB | 15 | 10 | 0.0 | 0 | 1 | 1 |
| Michael Lehan | CB | 15 | 9 | 0.0 | 0 | 1 | 0 |
| Gerard Warren | DT | 14 | 10 | 4.0 | 0 | 0 | 2 |
| Dyshod Carter | DB | 14 | 11 | 0.0 | 0 | 2 | 1 |
| Ben Taylor | LB | 8 | 2 | 0.0 | 0 | 0 | 0 |
| Dee Brown | RB | 6 | 2 | 0.0 | 0 | 0 | 0 |
| Amon Gordon | DE | 5 | 3 | 0.0 | 0 | 0 | 0 |
| Dennis Northcutt | WR | 4 | 4 | 0.0 | 0 | 0 | 0 |
| Aaron Shea | TE | 4 | 3 | 0.0 | 0 | 0 | 0 |
| Jeff Garcia | QB | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Andre Davis | WR | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Antonio Bryant | WR | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Steve Heiden | TE | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Sherrod Coates | LB | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Derrick Frost | P | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Richard Alston | WR | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Phil Dawson | K | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Damion Cook | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Courtney Brown | DE | 1 | 1 | 0.0 | 0 | 0 | 0 |
| William Green | RB | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Frisman Jackson | WR | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Jeff Faine | C | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Nick Eason | DE | 1 | 0 | 0.0 | 0 | 0 | 0 |