Franchise 74 seasons 523–560–11 all-time 26 playoff trips 0 Super Bowls
2006 players
Passing
| Charlie Frye | 391 | 251 | 2,449 | 10 | 17 | 6.3 |
| Derek Anderson | 117 | 66 | 793 | 5 | 8 | 6.8 |
| Josh Cribbs | 1 | 0 | 0 | 0 | 0 | 0.0 |
| Ken Dorsey | 1 | 0 | 0 | 0 | 0 | 0.0 |
Rushing
| Reuben Droughns | 220 | 758 | 4 | 3.4 |
| Charlie Frye | 47 | 215 | 3 | 4.6 |
| Jason Wright | 62 | 189 | 0 | 3.0 |
| Jerome Harrison | 20 | 60 | 0 | 3.0 |
| Derek Anderson | 4 | 47 | 0 | 11.8 |
| Dennis Northcutt | 3 | 32 | 0 | 10.7 |
| Terrelle Smith | 8 | 14 | 0 | 1.8 |
| Braylon Edwards | 4 | 12 | 0 | 3.0 |
| Josh Cribbs | 2 | 11 | 0 | 5.5 |
| Lawrence Vickers | 3 | 2 | 0 | 0.7 |
Receiving
| Braylon Edwards | 60 | 879 | 6 | 14.6 |
| Kellen Winslow | 89 | 875 | 3 | 9.8 |
| Joe Jurevicius | 40 | 495 | 3 | 12.4 |
| Steve Heiden | 36 | 249 | 2 | 6.9 |
| Dennis Northcutt | 22 | 228 | 0 | 10.4 |
| Reuben Droughns | 27 | 169 | 0 | 6.3 |
| Josh Cribbs | 10 | 91 | 0 | 9.1 |
| Jason Wright | 6 | 82 | 0 | 13.7 |
| Lawrence Vickers | 6 | 60 | 0 | 10.0 |
| Jerome Harrison | 9 | 47 | 0 | 5.2 |
| Travis Wilson | 2 | 32 | 0 | 16.0 |
| Terrelle Smith | 8 | 21 | 0 | 2.6 |
| Darnell Dinkins | 2 | 14 | 1 | 7.0 |