Franchise 74 seasons 523–560–11 all-time 26 playoff trips 0 Super Bowls
2010 players
Passing
| Colt McCoy | 222 | 135 | 1,576 | 6 | 9 | 7.1 |
| Jake Delhomme | 149 | 93 | 872 | 2 | 7 | 5.9 |
| Seneca Wallace | 101 | 64 | 694 | 4 | 2 | 6.9 |
| Mohamed Massaquoi | 1 | 1 | 29 | 1 | 0 | 29.0 |
| Josh Cribbs | 3 | 2 | 19 | 0 | 0 | 6.3 |
| Peyton Hillis | 2 | 1 | 13 | 0 | 0 | 6.5 |
Rushing
| Peyton Hillis | 270 | 1,177 | 11 | 4.4 |
| Colt McCoy | 28 | 136 | 1 | 4.9 |
| Mike Bell | 47 | 99 | 0 | 2.1 |
| Reggie Hodges | 1 | 68 | 0 | 68.0 |
| Josh Cribbs | 21 | 67 | 0 | 3.2 |
| Lawrence Vickers | 5 | 11 | 0 | 2.2 |
| Carlton Mitchell | 1 | 9 | 0 | 9.0 |
| Seneca Wallace | 7 | 9 | 0 | 1.3 |
| Chansi Stuckey | 3 | 9 | 1 | 3.0 |
| Benjamin Watson | 1 | -1 | 0 | -1.0 |
| Jake Delhomme | 8 | -2 | 0 | -0.2 |
| Mohamed Massaquoi | 1 | -3 | 0 | -3.0 |
| Yamon Figurs | 1 | -4 | 0 | -4.0 |
Receiving
| Benjamin Watson | 102 | 68 | 763 | 3 | 7.5 |
| Mohamed Massaquoi | 73 | 36 | 483 | 2 | 6.6 |
| Peyton Hillis | 77 | 61 | 477 | 2 | 6.2 |
| Chansi Stuckey | 63 | 40 | 346 | 0 | 5.5 |
| Evan Moore | 26 | 16 | 322 | 1 | 12.4 |
| Brian Robiskie | 49 | 29 | 310 | 3 | 6.3 |
| Josh Cribbs | 39 | 23 | 292 | 1 | 7.5 |
| Mike Bell | 10 | 7 | 67 | 0 | 6.7 |
| Robert Royal | 12 | 5 | 56 | 1 | 4.7 |
| Yamon Figurs | 2 | 2 | 17 | 0 | 8.5 |
| Lawrence Vickers | 9 | 4 | 15 | 0 | 1.7 |
| Colt McCoy | 1 | 1 | 13 | 0 | 13.0 |
| Seneca Wallace | 1 | 1 | 9 | 0 | 9.0 |
| Sam Aiken | 1 | 1 | 7 | 0 | 7.0 |
| Alex Smith | 1 | 1 | 6 | 0 | 6.0 |
Defense
| T.J. Ward | DB | 106 | 78 | 0.0 | 2 | 10 | 1 |
| Matt Roth | DE | 69 | 42 | 3.5 | 0 | 2 | 0 |
| Abram Elam | FS | 68 | 54 | 2.0 | 2 | 10 | 2 |
| Joe Haden | CB | 62 | 55 | 1.0 | 6 | 18 | 1 |
| Ahtyba Rubin | NT | 61 | 36 | 2.0 | 1 | 2 | 0 |
| Chris Gocong | LB | 59 | 34 | 2.0 | 0 | 3 | 1 |
| Kenyon Coleman | DE | 53 | 35 | 2.5 | 0 | 0 | 0 |
| Sheldon Brown | CB | 51 | 39 | 0.0 | 2 | 10 | 0 |
| Eric Barton | ILB | 46 | 27 | 0.0 | 0 | 1 | 0 |
| Scott Fujita | OLB | 41 | 26 | 3.5 | 1 | 1 | 2 |
| Eric Wright | DB | 36 | 30 | 0.0 | 1 | 9 | 0 |
| Mike Adams | FS | 34 | 27 | 1.0 | 2 | 6 | 0 |
| David Bowens | ILB | 34 | 20 | 0.5 | 2 | 6 | 0 |
| Brian Schaefering | NT | 29 | 22 | 0.0 | 0 | 0 | 0 |
| Marcus Benard | LB | 27 | 17 | 7.5 | 0 | 2 | 0 |
| Sabby Piscitelli | S | 22 | 21 | 0.0 | 1 | 1 | 0 |
| Raymond Ventrone | DB | 19 | 18 | 0.0 | 0 | 0 | 1 |
| Robaire Smith | DE | 18 | 6 | 0.0 | 0 | 0 | 0 |
| Derreck Robinson | DE | 18 | 7 | 0.5 | 0 | 0 | 0 |
| Jason Trusnik | LB | 17 | 14 | 1.0 | 0 | 1 | 0 |
| Shaun Rogers | DT | 12 | 9 | 2.0 | 0 | 0 | 0 |
| Nick Sorensen | DB | 12 | 8 | 0.0 | 0 | 0 | 0 |
| Titus Brown | LB | 11 | 8 | 0.0 | 0 | 0 | 0 |
| Eric Alexander | LB | 9 | 6 | 0.0 | 0 | 0 | 1 |
| Blake Costanzo | OLB | 7 | 5 | 0.0 | 0 | 0 | 0 |
| Mohamed Massaquoi | WR | 4 | 4 | 0.0 | 0 | 0 | 0 |
| Alex Mack | C | 4 | 4 | 0.0 | 0 | 0 | 0 |
| Chansi Stuckey | WR | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Coye Francies | DB | 3 | 2 | 0.0 | 0 | 0 | 0 |
| Brian Robiskie | WR | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Joe Thomas | OT | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Benjamin Watson | TE | 2 | 2 | 0.0 | 0 | 0 | 0 |
| John St. Clair | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Phil Dawson | K | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Sam Aiken | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Alex Smith | TE | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Steve Octavien | LB | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Peyton Hillis | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Evan Moore | TE | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Kaluka Maiava | OLB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Travis Ivey | NT | 1 | 1 | 0.0 | 0 | 0 | 0 |