Franchise 74 seasons 523–560–11 all-time 26 playoff trips 0 Super Bowls
2021 players
Passing
| Baker Mayfield | 418 | 253 | 3,010 | 17 | 13 | 7.2 |
| Case Keenum | 72 | 47 | 462 | 3 | 1 | 6.4 |
| Nick Mullens | 30 | 20 | 147 | 1 | 0 | 4.9 |
Rushing
| Nick Chubb | 228 | 1,259 | 8 | 5.5 |
| D'Ernest Johnson | 100 | 534 | 3 | 5.3 |
| Kareem Hunt | 78 | 386 | 5 | 4.9 |
| Baker Mayfield | 37 | 134 | 1 | 3.6 |
| Jarvis Landry | 6 | 40 | 2 | 6.7 |
| Anthony Schwartz | 6 | 39 | 0 | 6.5 |
| Demetric Felton | 7 | 24 | 0 | 3.4 |
| Case Keenum | 12 | 22 | 0 | 1.8 |
| John Kelly | 2 | 13 | 0 | 6.5 |
| Johnny Stanton | 3 | 5 | 0 | 1.7 |
| David Njoku | 1 | 1 | 0 | 1.0 |
| Andy Janovich | 2 | 0 | 1 | 0.0 |
| Jamie Gillan | 1 | 0 | 0 | 0.0 |
Receiving
| Donovan Peoples-Jones | 58 | 34 | 597 | 3 | 10.3 |
| Jarvis Landry | 87 | 52 | 570 | 2 | 6.6 |
| David Njoku | 53 | 36 | 475 | 4 | 9.0 |
| Austin Hooper | 61 | 38 | 345 | 3 | 5.7 |
| Rashard Higgins | 47 | 24 | 275 | 1 | 5.9 |
| Harrison Bryant | 28 | 21 | 233 | 3 | 8.3 |
| Demetric Felton | 21 | 18 | 181 | 2 | 8.6 |
| Kareem Hunt | 27 | 22 | 174 | 0 | 6.4 |
| Nick Chubb | 25 | 20 | 174 | 1 | 7.0 |
| D'Ernest Johnson | 25 | 19 | 137 | 0 | 5.5 |
| Anthony Schwartz | 23 | 10 | 135 | 1 | 5.9 |
| Ja'Marcus Bradley | 4 | 4 | 64 | 0 | 16.0 |
| Andy Janovich | 4 | 3 | 9 | 0 | 2.2 |
| Johnny Stanton | 2 | 2 | 7 | 1 | 3.5 |