Franchise 57 seasons 499–381–6 all-time 24 playoff trips 3 Super Bowls
1999 players
Passing
| Brian Griese | 452 | 261 | 3,032 | 14 | 14 | 6.7 |
| Chris Miller | 81 | 46 | 527 | 2 | 1 | 6.5 |
| Bubby Brister | 20 | 12 | 87 | 0 | 3 | 4.4 |
| Rod Smith | 1 | 0 | 0 | 0 | 0 | 0.0 |
Rushing
| Olandis Gary | 276 | 1,159 | 7 | 4.2 |
| Terrell Davis | 67 | 211 | 2 | 3.1 |
| Derek Loville | 40 | 203 | 1 | 5.1 |
| Brian Griese | 46 | 138 | 2 | 3.0 |
| Howard Griffith | 17 | 66 | 1 | 3.9 |
| Chris Miller | 8 | 40 | 0 | 5.0 |
| Bubby Brister | 2 | 17 | 0 | 8.5 |
| Detron Smith | 1 | 7 | 0 | 7.0 |
| Anthony Lynn | 2 | 2 | 0 | 1.0 |
| Tom Rouen | 1 | 0 | 0 | 0.0 |
Receiving
| Rod Smith | 139 | 79 | 1,020 | 4 | 7.3 |
| Ed McCaffrey | 127 | 71 | 1,018 | 7 | 8.0 |
| Byron Chamberlain | 57 | 32 | 488 | 2 | 8.6 |
| Shannon Sharpe | 37 | 23 | 224 | 0 | 6.1 |
| Dwayne Carswell | 38 | 24 | 201 | 2 | 5.3 |
| Howard Griffith | 39 | 26 | 192 | 1 | 4.9 |
| Olandis Gary | 29 | 21 | 159 | 0 | 5.5 |
| Andre Cooper | 17 | 9 | 98 | 0 | 5.8 |
| Billy Miller | 10 | 5 | 59 | 0 | 5.9 |
| Derek Loville | 16 | 11 | 50 | 0 | 3.1 |
| Travis McGriff | 7 | 3 | 37 | 0 | 5.3 |
| Terrell Davis | 3 | 3 | 26 | 0 | 8.7 |
| Detron Smith | 5 | 4 | 23 | 0 | 4.6 |
| Chris Doering | 5 | 3 | 22 | 0 | 4.4 |
| Desmond Clark | 1 | 1 | 5 | 0 | 5.0 |
Defense
| Glenn Cadrez | LLB | 82 | 61 | 7.0 | 0 | 7 | 3 |
| Al Wilson | MLB | 77 | 62 | 1.0 | 0 | 4 | 2 |
| Eric Brown | FS | 75 | 61 | 1.5 | 1 | 1 | 0 |
| Bill Romanowski | RLB | 73 | 57 | 0.0 | 3 | 7 | 1 |
| Dale Carter | RCB | 72 | 55 | 0.0 | 2 | 12 | 0 |
| Ray Crockett | LCB | 64 | 61 | 2.0 | 2 | 10 | 2 |
| Tyrone Braxton | SS | 56 | 43 | 1.0 | 0 | 0 | 0 |
| Trevor Pryce | RDT | 46 | 33 | 13.0 | 1 | 4 | 3 |
| Darrius Johnson | DB | 42 | 36 | 0.0 | 0 | 3 | 0 |
| George Coghill | SS | 39 | 31 | 0.0 | 1 | 4 | 1 |
| Maa Tanuvasa | RDE/LDE | 39 | 32 | 7.0 | 0 | 0 | 2 |
| Tory James | DB | 36 | 34 | 0.0 | 5 | 11 | 1 |
| Keith Traylor | LDT | 32 | 26 | 1.5 | 0 | 4 | 1 |
| Neil Smith | LDE | 31 | 25 | 6.5 | 0 | 1 | 0 |
| Harald Hasselbach | DE | 25 | 18 | 2.5 | 0 | 0 | 0 |
| Nate Wayne | LB | 16 | 13 | 2.0 | 0 | 0 | 1 |
| Mike Lodish | DT | 16 | 9 | 0.0 | 0 | 0 | 0 |
| Alfred Williams | RDE | 16 | 14 | 4.0 | 0 | 1 | 2 |
| David Bowens | DE | 15 | 15 | 1.0 | 0 | 0 | 0 |
| Chris Watson | DB | 12 | 12 | 0.0 | 0 | 2 | 0 |
| Montae Reagor | DT | 10 | 9 | 0.0 | 0 | 0 | 0 |
| John Mobley | LB | 10 | 7 | 0.0 | 0 | 1 | 0 |
| Jason Moore | DB | 8 | 7 | 0.0 | 0 | 0 | 0 |
| Paul Grasmanis | DT | 7 | 5 | 0.0 | 0 | 0 | 0 |
| Artie Ulmer | LB | 5 | 5 | 0.0 | 0 | 0 | 0 |
| Steve Russ | LB | 5 | 4 | 0.0 | 0 | 0 | 0 |
| Cyron Brown | DE | 4 | 4 | 0.0 | 0 | 0 | 0 |
| Trey Teague | LS | 3 | 1 | 0.0 | 0 | 0 | 0 |
| Matt Lepsis | OT | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Jason Suttle | DB | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Tony Jones | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Dan Neil | G | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Tom Nalen | C | 1 | 1 | 0.0 | 0 | 0 | 0 |