Franchise 57 seasons 499–381–6 all-time 24 playoff trips 3 Super Bowls
2000 players
Passing
| Brian Griese | 336 | 216 | 2,688 | 19 | 4 | 8.0 |
| Gus Frerotte | 232 | 138 | 1,776 | 9 | 8 | 7.7 |
| Jarious Jackson | 1 | 0 | 0 | 0 | 0 | 0.0 |
Rushing
| Mike Anderson | 297 | 1,500 | 15 | 5.1 |
| Terrell Davis | 78 | 282 | 2 | 3.6 |
| KaRon Coleman | 54 | 183 | 1 | 3.4 |
| Brian Griese | 29 | 102 | 1 | 3.5 |
| Rod Smith | 6 | 99 | 1 | 16.5 |
| Olandis Gary | 13 | 80 | 0 | 6.2 |
| Gus Frerotte | 22 | 64 | 1 | 2.9 |
| Howard Griffith | 5 | 4 | 0 | 0.8 |
| Jarious Jackson | 1 | -1 | 0 | -1.0 |
| Tom Rouen | 1 | -11 | 0 | -11.0 |
Receiving
| Rod Smith | 173 | 100 | 1,602 | 8 | 9.3 |
| Ed McCaffrey | 149 | 101 | 1,317 | 9 | 8.8 |
| Dwayne Carswell | 64 | 49 | 495 | 3 | 7.7 |
| Desmond Clark | 38 | 27 | 339 | 3 | 8.9 |
| Byron Chamberlain | 32 | 22 | 283 | 1 | 8.8 |
| Mike Anderson | 32 | 23 | 169 | 0 | 5.3 |
| Howard Griffith | 31 | 16 | 101 | 2 | 3.3 |
| Robert Brooks | 4 | 3 | 51 | 0 | 12.8 |
| Travis McGriff | 8 | 2 | 51 | 1 | 6.4 |
| Scottie Montgomery | 1 | 1 | 10 | 0 | 10.0 |
| Olandis Gary | 4 | 3 | 10 | 0 | 2.5 |
| Billy Miller | 4 | 1 | 7 | 0 | 1.8 |
| KaRon Coleman | 3 | 1 | 5 | 0 | 1.7 |
| Terrell Davis | 2 | 2 | 4 | 0 | 2.0 |
| Detron Smith | 3 | 1 | 1 | 1 | 0.3 |
Defense
| Eric Brown | S | 86 | 72 | 1.0 | 3 | 7 | 0 |
| Billy Jenkins | S | 85 | 69 | 0.0 | 4 | 11 | 1 |
| John Mobley | OLB | 77 | 60 | 2.0 | 1 | 11 | 2 |
| Bill Romanowski | OLB | 65 | 55 | 3.5 | 2 | 6 | 4 |
| Al Wilson | MLB | 56 | 43 | 5.0 | 3 | 8 | 0 |
| Ray Crockett | CB | 45 | 42 | 1.0 | 4 | 12 | 1 |
| Trevor Pryce | DE | 41 | 28 | 12.0 | 0 | 5 | 2 |
| Jimmy Spencer | DB | 38 | 35 | 1.0 | 3 | 8 | 1 |
| Terrell Buckley | DB | 35 | 32 | 0.0 | 6 | 12 | 0 |
| Keith Traylor | NT | 31 | 26 | 1.0 | 0 | 2 | 2 |
| Maa Tanuvasa | DE | 28 | 20 | 4.0 | 0 | 1 | 0 |
| Kavika Pittman | DE | 26 | 24 | 7.0 | 0 | 2 | 1 |
| Ian Gold | OLB | 26 | 21 | 2.0 | 0 | 1 | 1 |
| George Coghill | DB | 22 | 20 | 0.0 | 0 | 0 | 1 |
| Keith Burns | LB | 21 | 18 | 0.0 | 0 | 1 | 3 |
| Kenoy Kennedy | S | 11 | 8 | 0.0 | 1 | 1 | 0 |
| Montae Reagor | DE | 10 | 8 | 2.0 | 0 | 1 | 0 |
| Harald Hasselbach | DE | 9 | 7 | 2.5 | 0 | 0 | 1 |
| Deltha O'Neal | CB | 8 | 8 | 0.0 | 0 | 3 | 1 |
| Mike Lodish | DT | 8 | 7 | 0.0 | 0 | 0 | 0 |
| Glenn Cadrez | OLB | 8 | 8 | 0.0 | 0 | 2 | 0 |
| Detron Smith | RB | 7 | 7 | 0.0 | 0 | 0 | 2 |
| Darryl Pounds | CB | 7 | 6 | 0.0 | 0 | 0 | 0 |
| Billy Miller | TE | 6 | 5 | 0.0 | 0 | 0 | 0 |
| Chris Cole | WR | 6 | 4 | 0.0 | 0 | 0 | 0 |
| Byron Chamberlain | TE | 4 | 3 | 0.0 | 0 | 0 | 0 |
| Jason Suttle | DB | 4 | 4 | 0.0 | 0 | 0 | 0 |
| Mike Anderson | RB | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Desmond Clark | TE | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Ed McCaffrey | WR | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Dwayne Carswell | OT | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Steve Lindsey | K | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Scottie Montgomery | WR | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Tom Nalen | C | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Howard Griffith | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Gus Frerotte | QB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Travis McGriff | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Steve Russ | LB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Tom Rouen | P | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Rod Smith | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Cooper Carlisle | G | 1 | 1 | 0.0 | 0 | 0 | 0 |