Franchise 57 seasons 499–381–6 all-time 24 playoff trips 3 Super Bowls
2001 players
Passing
| Brian Griese | 451 | 275 | 2,827 | 23 | 19 | 6.3 |
| Gus Frerotte | 48 | 30 | 308 | 3 | 0 | 6.4 |
| Jarious Jackson | 12 | 7 | 73 | 0 | 0 | 6.1 |
Rushing
| Terrell Davis | 167 | 701 | 0 | 4.2 |
| Mike Anderson | 175 | 678 | 4 | 3.9 |
| Olandis Gary | 57 | 228 | 1 | 4.0 |
| Brian Griese | 50 | 173 | 1 | 3.5 |
| Rod Smith | 3 | 27 | 0 | 9.0 |
| Kevin Kasper | 3 | 19 | 0 | 6.3 |
| KaRon Coleman | 4 | 17 | 0 | 4.2 |
| Gus Frerotte | 10 | 9 | 1 | 0.9 |
| Jarious Jackson | 5 | 7 | 0 | 1.4 |
| Scottie Montgomery | 1 | 5 | 0 | 5.0 |
| Tony Carter | 1 | 4 | 0 | 4.0 |
| Patrick Hape | 2 | 0 | 0 | 0.0 |
Receiving
| Rod Smith | 171 | 113 | 1,343 | 11 | 7.9 |
| Desmond Clark | 77 | 51 | 566 | 6 | 7.4 |
| Dwayne Carswell | 56 | 34 | 299 | 4 | 5.3 |
| Chris Cole | 19 | 9 | 128 | 0 | 6.7 |
| Scottie Montgomery | 22 | 11 | 99 | 0 | 4.5 |
| Patrick Hape | 19 | 15 | 96 | 3 | 5.1 |
| Ed McCaffrey | 7 | 6 | 94 | 1 | 13.4 |
| Kevin Kasper | 12 | 8 | 84 | 0 | 7.0 |
| Tony Carter | 16 | 11 | 83 | 0 | 5.2 |
| Terrell Davis | 21 | 12 | 69 | 0 | 3.3 |
| Mike Anderson | 12 | 8 | 46 | 0 | 3.8 |
| KaRon Coleman | 11 | 6 | 45 | 0 | 4.1 |
| Keith Poole | 10 | 5 | 38 | 0 | 3.8 |
| Olandis Gary | 5 | 4 | 29 | 0 | 5.8 |
| Matt Dominguez | 5 | 3 | 26 | 0 | 5.2 |
| Brian Griese | 1 | 1 | -6 | 0 | -6.0 |
Defense
| John Mobley | OLB | 83 | 70 | 1.0 | 1 | 6 | 1 |
| Al Wilson | MLB | 74 | 61 | 3.0 | 0 | 5 | 0 |
| Eric Brown | S | 69 | 56 | 3.0 | 2 | 9 | 1 |
| Kenoy Kennedy | S | 68 | 49 | 2.0 | 1 | 6 | 0 |
| Bill Romanowski | OLB | 64 | 50 | 7.0 | 0 | 2 | 2 |
| Deltha O'Neal | CB | 61 | 54 | 0.0 | 9 | 25 | 0 |
| Denard Walker | CB | 53 | 48 | 0.0 | 3 | 5 | 0 |
| Ian Gold | OLB | 38 | 33 | 3.0 | 0 | 3 | 1 |
| Trevor Pryce | DE | 36 | 29 | 7.0 | 0 | 4 | 1 |
| Jimmy Spencer | DB | 35 | 33 | 0.0 | 3 | 9 | 0 |
| Chester McGlockton | DT | 35 | 30 | 1.0 | 2 | 5 | 0 |
| Keith Washington | DE | 33 | 24 | 4.0 | 0 | 0 | 1 |
| Kavika Pittman | DE | 28 | 22 | 1.0 | 0 | 2 | 1 |
| George Coghill | DB | 23 | 20 | 0.0 | 1 | 1 | 2 |
| Bertrand Berry | OLB | 20 | 18 | 2.0 | 0 | 1 | 0 |
| Keith Burns | LB | 17 | 14 | 0.0 | 0 | 0 | 1 |
| Reggie Hayward | DE | 15 | 12 | 3.0 | 0 | 0 | 0 |
| Eric Davis | FS | 13 | 13 | 0.0 | 0 | 1 | 1 |
| Leon Lett | DE | 10 | 10 | 0.0 | 0 | 2 | 0 |
| Chris Cole | WR | 9 | 7 | 0.0 | 0 | 0 | 1 |
| Montae Reagor | DE | 9 | 7 | 1.0 | 0 | 1 | 0 |
| Lee Woodall | LB | 9 | 7 | 1.0 | 0 | 0 | 0 |
| Detron Smith | RB | 7 | 5 | 0.0 | 0 | 0 | 0 |
| Kevin Kasper | WR | 6 | 3 | 0.0 | 0 | 0 | 0 |
| Rod Smith | WR | 5 | 5 | 0.0 | 0 | 0 | 1 |
| David Diaz-Infante | G | 4 | 3 | 0.0 | 0 | 0 | 0 |
| Brian Griese | QB | 4 | 4 | 0.0 | 0 | 0 | 0 |
| Jerry Johnson | DT | 4 | 2 | 0.0 | 0 | 0 | 0 |
| Darius Clark | DB | 3 | 2 | 0.0 | 0 | 0 | 0 |
| Tom Nalen | C | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Olandis Gary | RB | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Scottie Montgomery | WR | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Dwayne Carswell | OT | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Tony Carter | RB | 1 | 1 | 0.0 | 0 | 0 | 1 |
| Terrell Davis | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Desmond Clark | TE | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Patrick Hape | TE | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Matt Lepsis | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Keith Poole | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Jason Elam | K | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Jarious Jackson | QB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Willie Middlebrooks | DB | 1 | 1 | 0.0 | 0 | 0 | 0 |