Franchise 57 seasons 499–381–6 all-time 24 playoff trips 3 Super Bowls
2016 players
Passing
| Trevor Siemian | 486 | 289 | 3,401 | 18 | 10 | 7.0 |
| Paxton Lynch | 83 | 49 | 497 | 2 | 1 | 6.0 |
| Riley Dixon | 1 | 1 | 16 | 0 | 0 | 16.0 |
Rushing
| Devontae Booker | 174 | 612 | 4 | 3.5 |
| C.J. Anderson | 110 | 437 | 4 | 4.0 |
| Justin Forsett | 87 | 291 | 1 | 3.3 |
| Kapri Bibbs | 29 | 129 | 0 | 4.4 |
| Trevor Siemian | 28 | 57 | 0 | 2.0 |
| Andy Janovich | 4 | 33 | 1 | 8.2 |
| Juwan Thompson | 8 | 26 | 1 | 3.2 |
| Paxton Lynch | 11 | 25 | 0 | 2.3 |
| Brandon McManus | 1 | 6 | 0 | 6.0 |
| Emmanuel Sanders | 1 | 4 | 0 | 4.0 |
| Jordan Norwood | 1 | 0 | 0 | 0.0 |
Receiving
| Demaryius Thomas | 144 | 90 | 1,083 | 5 | 7.5 |
| Emmanuel Sanders | 137 | 79 | 1,032 | 5 | 7.5 |
| Devontae Booker | 45 | 31 | 265 | 1 | 5.9 |
| Virgil Green | 37 | 22 | 237 | 1 | 6.4 |
| Jordan Norwood | 35 | 21 | 232 | 1 | 6.6 |
| Jordan Taylor | 25 | 16 | 209 | 2 | 8.4 |
| A.J. Derby | 20 | 16 | 160 | 0 | 8.0 |
| Bennie Fowler | 24 | 11 | 145 | 2 | 6.0 |
| Jeff Heuerman | 17 | 9 | 141 | 0 | 8.3 |
| C.J. Anderson | 24 | 16 | 128 | 1 | 5.3 |
| Justin Forsett | 27 | 20 | 85 | 0 | 3.1 |
| Cody Latimer | 15 | 8 | 76 | 0 | 5.1 |
| Kapri Bibbs | 4 | 2 | 75 | 1 | 18.8 |
| Andy Janovich | 7 | 5 | 44 | 0 | 6.3 |
| Henry Krieger-Coble | 1 | 1 | 13 | 0 | 13.0 |
Defense
| Todd Davis | ILB | 95 | 62 | 0.5 | 0 | 3 | 1 |
| T.J. Ward | DB | 81 | 63 | 1.0 | 1 | 8 | 3 |
| Von Miller | OLB | 72 | 56 | 13.5 | 0 | 3 | 3 |
| Darian Stewart | S | 66 | 53 | 0.0 | 3 | 6 | 1 |
| Corey Nelson | ILB | 66 | 45 | 0.0 | 0 | 5 | 0 |
| Chris Harris | CB | 58 | 52 | 0.0 | 2 | 10 | 1 |
| Jared Crick | DE | 52 | 31 | 3.0 | 0 | 6 | 2 |
| Brandon Marshall | ILB | 47 | 34 | 0.0 | 0 | 3 | 0 |
| Derek Wolfe | DE | 46 | 33 | 5.5 | 0 | 4 | 0 |
| Shane Ray | LB | 46 | 31 | 8.0 | 0 | 0 | 1 |
| Aqib Talib | CB | 42 | 31 | 0.0 | 3 | 12 | 0 |
| Bradley Roby | CB | 38 | 33 | 1.0 | 2 | 8 | 1 |
| Shaquil Barrett | LB | 36 | 23 | 1.5 | 0 | 2 | 1 |
| Justin Simmons | FS | 30 | 25 | 1.0 | 2 | 4 | 0 |
| Sylvester Williams | DT | 29 | 20 | 1.0 | 0 | 1 | 0 |
| Will Parks | S | 22 | 17 | 0.0 | 1 | 3 | 0 |
| Billy Winn | DE | 19 | 8 | 0.0 | 0 | 0 | 0 |
| Dekoda Watson | LB | 16 | 12 | 1.0 | 0 | 0 | 1 |
| DeMarcus Ware | OLB | 14 | 8 | 4.0 | 0 | 1 | 0 |
| Adam Gotsis | DE | 13 | 4 | 0.0 | 0 | 1 | 0 |
| Zaire Anderson | ILB | 13 | 8 | 0.0 | 0 | 0 | 1 |
| Kayvon Webster | S | 7 | 6 | 0.0 | 0 | 1 | 0 |
| Cody Latimer | WR | 7 | 7 | 0.0 | 0 | 0 | 0 |
| Bennie Fowler | WR | 6 | 6 | 0.0 | 0 | 0 | 0 |
| Darius Kilgo | NT | 5 | 2 | 0.0 | 0 | 0 | 0 |
| Max Garcia | G | 4 | 4 | 0.0 | 0 | 0 | 0 |
| Donald Stephenson | OT | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Brandon McManus | K | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Lorenzo Doss | CB | 3 | 3 | 0.0 | 0 | 2 | 0 |
| Jordan Taylor | WR | 3 | 2 | 0.0 | 0 | 0 | 0 |
| Kyle Peko | DE | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Quentin Gause | LB | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Andy Janovich | FB | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Demaryius Thomas | WR | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Jordan Norwood | WR | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Russell Okung | OT | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Kapri Bibbs | RB | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Thomas Gafford | LS | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Virgil Green | TE | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Emmanuel Sanders | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Casey Kreiter | LS | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Juwan Thompson | RB | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Michael Schofield | G | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Trevor Siemian | QB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Taurean Nixon | CB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Devontae Booker | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |