Franchise 57 seasons 499–381–6 all-time 24 playoff trips 3 Super Bowls
2018 players
Passing
| Case Keenum | 586 | 365 | 3,890 | 18 | 15 | 6.6 |
| Emmanuel Sanders | 1 | 1 | 28 | 1 | 0 | 28.0 |
| Colby Wadman | 1 | 1 | 12 | 0 | 0 | 12.0 |
Rushing
| Phillip Lindsay | 192 | 1,037 | 9 | 5.4 |
| Royce Freeman | 130 | 521 | 5 | 4.0 |
| Devontae Booker | 34 | 183 | 1 | 5.4 |
| Case Keenum | 26 | 93 | 2 | 3.6 |
| Emmanuel Sanders | 4 | 53 | 1 | 13.2 |
| Tim Patrick | 3 | 17 | 0 | 5.7 |
| Andy Janovich | 2 | 5 | 0 | 2.5 |
| Chad Kelly | 1 | -1 | 0 | -1.0 |
| Courtland Sutton | 1 | -1 | 0 | -1.0 |
Receiving
| Emmanuel Sanders | 98 | 71 | 868 | 4 | 8.9 |
| Courtland Sutton | 84 | 42 | 704 | 4 | 8.4 |
| Tim Patrick | 41 | 23 | 315 | 1 | 7.7 |
| Jeff Heuerman | 48 | 31 | 281 | 2 | 5.9 |
| Devontae Booker | 51 | 38 | 275 | 0 | 5.4 |
| Matt LaCosse | 37 | 24 | 250 | 1 | 6.8 |
| DaeSean Hamilton | 46 | 30 | 243 | 2 | 5.3 |
| Phillip Lindsay | 47 | 35 | 241 | 1 | 5.1 |
| Andre Holmes | 24 | 13 | 162 | 0 | 6.8 |
| Andy Janovich | 10 | 8 | 112 | 1 | 11.2 |
| Jake Butt | 13 | 8 | 85 | 0 | 6.5 |
| Royce Freeman | 20 | 14 | 72 | 0 | 3.6 |
| River Cracraft | 2 | 1 | 44 | 0 | 22.0 |
| Brian Parker | 10 | 5 | 33 | 0 | 3.3 |
Defense
| Todd Davis | ILB | 109 | 75 | 0.5 | 1 | 7 | 0 |
| Justin Simmons | FS | 94 | 68 | 0.0 | 3 | 4 | 0 |
| Bradley Chubb | OLB | 59 | 40 | 12.0 | 0 | 1 | 2 |
| Darian Stewart | S | 56 | 42 | 1.0 | 2 | 3 | 0 |
| Josey Jewell | ILB | 53 | 33 | 0.0 | 0 | 3 | 0 |
| Chris Harris | CB | 48 | 39 | 1.0 | 3 | 10 | 0 |
| Bradley Roby | CB | 48 | 43 | 0.0 | 1 | 12 | 2 |
| Von Miller | OLB | 47 | 28 | 14.5 | 1 | 3 | 4 |
| Brandon Marshall | ILB | 42 | 22 | 0.0 | 0 | 1 | 0 |
| Will Parks | S | 39 | 23 | 0.0 | 1 | 4 | 1 |
| Shelby Harris | DT | 37 | 21 | 1.5 | 1 | 4 | 0 |
| Adam Gotsis | DE | 35 | 22 | 3.0 | 0 | 6 | 2 |
| Derek Wolfe | DE | 34 | 22 | 1.5 | 1 | 6 | 0 |
| Domata Peko Sr. | NT | 29 | 18 | 0.5 | 0 | 2 | 0 |
| Zach Kerr | DE | 29 | 11 | 1.5 | 0 | 1 | 0 |
| Shaquil Barrett | LB | 28 | 22 | 3.0 | 0 | 1 | 0 |
| Tramaine Brock | DB | 23 | 19 | 0.0 | 0 | 6 | 0 |
| Isaac Yiadom | CB | 20 | 17 | 0.0 | 1 | 3 | 0 |
| Jamar Taylor | CB | 18 | 16 | 0.0 | 0 | 1 | 1 |
| Su'a Cravens | DB | 17 | 10 | 0.0 | 0 | 0 | 0 |
| Joe Jones | LB | 16 | 13 | 0.0 | 0 | 0 | 0 |
| Shane Ray | LB | 10 | 6 | 1.0 | 0 | 1 | 1 |
| Dymonte Thomas | DB | 10 | 6 | 1.0 | 1 | 1 | 0 |
| Adam Jones | DB | 9 | 9 | 0.0 | 1 | 3 | 0 |
| Tim Patrick | WR | 8 | 6 | 0.0 | 0 | 0 | 0 |
| Shamarko Thomas | DB | 7 | 5 | 0.0 | 0 | 0 | 0 |
| Andy Janovich | FB | 7 | 6 | 0.0 | 0 | 0 | 0 |
| Andre Holmes | WR | 6 | 6 | 0.0 | 0 | 0 | 0 |
| Jeff Holland | LB | 5 | 0 | 0.0 | 0 | 0 | 0 |
| Devontae Booker | RB | 4 | 2 | 0.0 | 0 | 0 | 0 |
| DeMarcus Walker | DE | 4 | 2 | 1.0 | 0 | 0 | 0 |
| Keishawn Bierria | LB | 4 | 2 | 0.0 | 0 | 0 | 0 |
| Brendan Langley | WR | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Phillip Lindsay | RB | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Courtland Sutton | WR | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Matt Paradis | C | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Brian Parker | TE | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Jeff Heuerman | TE | 2 | 2 | 0.0 | 0 | 0 | 0 |
| DaeSean Hamilton | WR | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Jared Veldheer | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Brandon McManus | K | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Temarrick Hemingway | TE | 1 | 1 | 0.0 | 0 | 0 | 0 |
| River Cracraft | WR | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Elijah Wilkinson | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Garett Bolles | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Jake Butt | TE | 1 | 1 | 0.0 | 0 | 0 | 0 |