Franchise 57 seasons 499–381–6 all-time 24 playoff trips 3 Super Bowls
2020 players
Passing
| Drew Lock | 443 | 254 | 2,933 | 16 | 15 | 6.6 |
| Jeff Driskel | 64 | 35 | 432 | 3 | 2 | 6.8 |
| Brett Rypien | 40 | 27 | 295 | 2 | 4 | 7.4 |
| Kendall Hinton | 9 | 1 | 13 | 0 | 2 | 1.4 |
Rushing
| Melvin Gordon | 215 | 986 | 9 | 4.6 |
| Phillip Lindsay | 118 | 502 | 1 | 4.3 |
| Royce Freeman | 35 | 170 | 0 | 4.9 |
| Drew Lock | 44 | 160 | 3 | 3.6 |
| KJ Hamler | 9 | 40 | 0 | 4.4 |
| Jeff Driskel | 6 | 28 | 0 | 4.7 |
| Diontae Spencer | 3 | 19 | 0 | 6.3 |
| Levante Bellamy | 4 | 11 | 0 | 2.8 |
| Kendall Hinton | 2 | 7 | 0 | 3.5 |
| Sam Martin | 1 | 0 | 0 | 0.0 |
| Brett Rypien | 5 | -5 | 0 | -1.0 |
Receiving
| Jerry Jeudy | 113 | 52 | 856 | 3 | 7.6 |
| Tim Patrick | 79 | 51 | 742 | 6 | 9.4 |
| Noah Fant | 93 | 62 | 673 | 3 | 7.2 |
| KJ Hamler | 56 | 30 | 381 | 3 | 6.8 |
| DaeSean Hamilton | 44 | 23 | 293 | 2 | 6.7 |
| Melvin Gordon | 44 | 32 | 158 | 1 | 3.6 |
| Albert Okwuegbunam | 15 | 11 | 121 | 1 | 8.1 |
| Nick Vannett | 21 | 14 | 95 | 1 | 4.5 |
| Royce Freeman | 13 | 12 | 81 | 0 | 6.2 |
| Troy Fumagalli | 15 | 8 | 80 | 1 | 5.3 |
| Courtland Sutton | 6 | 3 | 66 | 0 | 11.0 |
| Tyrie Cleveland | 9 | 6 | 63 | 0 | 7.0 |
| Phillip Lindsay | 14 | 7 | 28 | 0 | 2.0 |
| Diontae Spencer | 6 | 3 | 26 | 0 | 4.3 |
| Jake Butt | 4 | 2 | 5 | 0 | 1.2 |
| Levante Bellamy | 1 | 1 | 5 | 0 | 5.0 |