Franchise 57 seasons 499–381–6 all-time 24 playoff trips 3 Super Bowls
2021 players
Passing
| Teddy Bridgewater | 426 | 285 | 3,052 | 18 | 7 | 7.2 |
| Drew Lock | 111 | 67 | 787 | 2 | 2 | 7.1 |
| Courtland Sutton | 1 | 1 | 16 | 0 | 0 | 16.0 |
| Kendall Hinton | 1 | 1 | 1 | 0 | 0 | 1.0 |
| Brett Rypien | 2 | 0 | 0 | 0 | 0 | 0.0 |
Rushing
| Melvin Gordon | 203 | 918 | 8 | 4.5 |
| Javonte Williams | 203 | 903 | 4 | 4.4 |
| Teddy Bridgewater | 30 | 106 | 2 | 3.5 |
| Drew Lock | 10 | 53 | 2 | 5.3 |
| Mike Boone | 4 | 35 | 0 | 8.8 |
| Damarea Crockett | 3 | 7 | 0 | 2.3 |
| Jerry Jeudy | 2 | 3 | 0 | 1.5 |
Receiving
| Courtland Sutton | 98 | 58 | 776 | 2 | 7.9 |
| Tim Patrick | 85 | 53 | 734 | 5 | 8.6 |
| Noah Fant | 90 | 68 | 670 | 4 | 7.4 |
| Jerry Jeudy | 56 | 38 | 467 | 0 | 8.3 |
| Albert Okwuegbunam | 40 | 33 | 330 | 2 | 8.2 |
| Javonte Williams | 53 | 43 | 316 | 3 | 6.0 |
| Melvin Gordon | 38 | 28 | 213 | 2 | 5.6 |
| Kendall Hinton | 23 | 15 | 175 | 1 | 7.6 |
| KJ Hamler | 10 | 5 | 74 | 0 | 7.4 |
| Eric Saubert | 12 | 8 | 47 | 1 | 3.9 |
| Seth Williams | 1 | 1 | 34 | 0 | 34.0 |
| Mike Boone | 2 | 2 | 22 | 0 | 11.0 |
| Drew Lock | 1 | 1 | 1 | 0 | 1.0 |
| Diontae Spencer | 4 | 1 | -3 | 0 | -0.8 |