Franchise 77 seasons 510–610–21 all-time 18 playoff trips 0 Super Bowls
2005 players
Passing
| Joey Harrington | 331 | 189 | 2,021 | 12 | 12 | 6.1 |
| Jeff Garcia | 173 | 102 | 937 | 3 | 6 | 5.4 |
| Dan Orlovsky | 17 | 7 | 63 | 0 | 0 | 3.7 |
Rushing
| Kevin Jones | 186 | 664 | 5 | 3.6 |
| Artose Pinner | 106 | 349 | 3 | 3.3 |
| Shawn Bryson | 64 | 306 | 1 | 4.8 |
| Joey Harrington | 25 | 80 | 0 | 3.2 |
| Jeff Garcia | 17 | 51 | 1 | 3.0 |
| Paul Smith | 4 | 16 | 0 | 4.0 |
| Scott Vines | 1 | 7 | 0 | 7.0 |
| Cory Schlesinger | 1 | 1 | 0 | 1.0 |
| Eddie Drummond | 1 | -3 | 0 | -3.0 |
Receiving
| Roy Williams | 45 | 687 | 8 | 15.3 |
| Marcus Pollard | 47 | 516 | 3 | 11.0 |
| Scott Vines | 40 | 417 | 0 | 10.4 |
| Mike Williams | 29 | 350 | 1 | 12.1 |
| Shawn Bryson | 37 | 284 | 0 | 7.7 |
| Charles Rogers | 14 | 197 | 1 | 14.1 |
| Artose Pinner | 21 | 181 | 0 | 8.6 |
| Kevin Johnson | 17 | 133 | 0 | 7.8 |
| Kevin Jones | 20 | 109 | 0 | 5.4 |
| Paul Smith | 6 | 49 | 0 | 8.2 |
| Casey Fitzsimmons | 10 | 45 | 1 | 4.5 |
| Cory Schlesinger | 8 | 31 | 1 | 3.9 |
| Troy Edwards | 2 | 15 | 0 | 7.5 |
| Glenn Martinez | 1 | 11 | 0 | 11.0 |
| Joey Harrington | 1 | -4 | 0 | -4.0 |
Defense
| Kenoy Kennedy | S | 94 | 70 | 0.0 | 2 | 6 | 1 |
| Earl Holmes | MLB | 65 | 41 | 0.0 | 0 | 1 | 2 |
| James Davis | OLB | 56 | 32 | 0.0 | 0 | 0 | 0 |
| Boss Bailey | OLB | 53 | 33 | 1.0 | 1 | 3 | 0 |
| R.W. McQuarters | CB | 53 | 42 | 0.0 | 2 | 10 | 0 |
| James Hall | DE | 52 | 44 | 5.0 | 0 | 1 | 3 |
| Andre' Goodman | CB | 45 | 40 | 0.0 | 3 | 11 | 0 |
| Wali Rainer | LB | 44 | 34 | 0.0 | 0 | 0 | 0 |
| Dre' Bly | CB | 43 | 39 | 0.0 | 6 | 13 | 3 |
| Shaun Rogers | DT | 40 | 29 | 5.5 | 0 | 2 | 2 |
| Terrence Holt | DB | 40 | 30 | 0.0 | 2 | 5 | 1 |
| Donte Curry | LB | 36 | 26 | 0.0 | 0 | 0 | 0 |
| Bracy Walker | FS | 33 | 22 | 0.0 | 1 | 2 | 0 |
| Kalimba Edwards | DE | 29 | 22 | 7.0 | 0 | 2 | 2 |
| LeVar Woods | LB | 27 | 16 | 1.0 | 0 | 0 | 0 |
| Shaun Cody | NT | 27 | 16 | 1.5 | 0 | 0 | 1 |
| Cory Redding | DE | 27 | 20 | 1.0 | 0 | 4 | 1 |
| Dan Wilkinson | DT | 21 | 15 | 3.0 | 0 | 4 | 0 |
| Jared DeVries | DE | 21 | 15 | 3.0 | 0 | 1 | 0 |
| Jon McGraw | S | 20 | 15 | 0.0 | 0 | 0 | 0 |
| Keith Smith | DB | 19 | 15 | 1.0 | 0 | 1 | 0 |
| Marcus Bell | NT | 18 | 12 | 0.0 | 0 | 0 | 1 |
| Nate Wayne | LB | 13 | 10 | 0.0 | 1 | 1 | 1 |
| Teddy Lehman | LB | 13 | 8 | 0.0 | 1 | 2 | 0 |
| Vernon Fox | DB | 11 | 7 | 0.0 | 0 | 0 | 0 |
| Casey Fitzsimmons | TE | 11 | 11 | 0.0 | 0 | 0 | 1 |
| Stanley Wilson | CB | 10 | 9 | 0.0 | 0 | 0 | 0 |
| Fernando Bryant | DB | 8 | 7 | 0.0 | 0 | 1 | 1 |
| Shawn Bryson | RB | 7 | 6 | 0.0 | 0 | 0 | 0 |
| Artose Pinner | RB | 6 | 6 | 0.0 | 0 | 0 | 0 |
| Matt Grootegoed | LB | 4 | 2 | 0.0 | 0 | 0 | 0 |
| Kyle Kosier | G | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Mike Williams | WR | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Paul Smith | RB | 3 | 2 | 0.0 | 0 | 0 | 0 |
| Sean McHugh | TE | 3 | 2 | 0.0 | 0 | 0 | 0 |
| Roy Williams | WR | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Kelly Butler | OT | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Don Muhlbach | LS | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Rick DeMulling | OT | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Marcus Pollard | TE | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Jason Hanson | K | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Eddie Drummond | WR | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Kevin Johnson | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Damien Woody | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Cory Schlesinger | FB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Brock Gutierrez | G | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Nick Harris | P | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Joey Harrington | QB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Remy Hamilton | K | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Glenn Martinez | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Dan Orlovsky | QB | 1 | 1 | 0.0 | 0 | 0 | 0 |