Franchise 77 seasons 510–610–21 all-time 18 playoff trips 0 Super Bowls
2021 players
Passing
| Jared Goff | 494 | 332 | 3,245 | 19 | 8 | 6.6 |
| Tim Boyle | 94 | 61 | 526 | 3 | 6 | 5.6 |
| Tom Kennedy | 1 | 1 | 75 | 1 | 0 | 75.0 |
| Jack Fox | 3 | 2 | 38 | 0 | 0 | 12.7 |
| D'Andre Swift | 1 | 0 | 0 | 0 | 0 | 0.0 |
Rushing
| D'Andre Swift | 151 | 617 | 5 | 4.1 |
| Jamaal Williams | 153 | 601 | 3 | 3.9 |
| Craig Reynolds | 55 | 230 | 0 | 4.2 |
| Godwin Igwebuike | 18 | 118 | 1 | 6.6 |
| Jared Goff | 17 | 87 | 0 | 5.1 |
| Jermar Jefferson | 15 | 74 | 2 | 4.9 |
| Amon-Ra St. Brown | 7 | 61 | 1 | 8.7 |
| Kalif Raymond | 4 | 28 | 0 | 7.0 |
| C.J. Moore | 1 | 28 | 0 | 28.0 |
| Jason Cabinda | 3 | 23 | 0 | 7.7 |
| Tim Boyle | 2 | 13 | 0 | 6.5 |
| David Blough | 1 | 6 | 0 | 6.0 |
Receiving
| Amon-Ra St. Brown | 119 | 90 | 912 | 5 | 7.7 |
| T.J. Hockenson | 84 | 61 | 583 | 4 | 6.9 |
| Kalif Raymond | 71 | 48 | 576 | 4 | 8.1 |
| D'Andre Swift | 78 | 62 | 452 | 2 | 5.8 |
| Josh Reynolds | 49 | 29 | 396 | 2 | 8.1 |
| Quintez Cephus | 22 | 15 | 204 | 2 | 9.3 |
| Jamaal Williams | 28 | 26 | 157 | 0 | 5.6 |
| KhaDarel Hodge | 27 | 13 | 157 | 0 | 5.8 |
| Brock Wright | 17 | 12 | 117 | 2 | 6.9 |
| Trinity Benson | 22 | 10 | 103 | 0 | 4.7 |
| Godwin Igwebuike | 10 | 7 | 60 | 0 | 6.0 |
| Tom Kennedy | 10 | 6 | 54 | 0 | 5.4 |
| Craig Reynolds | 8 | 7 | 52 | 0 | 6.5 |
| Darren Fells | 5 | 4 | 43 | 0 | 8.6 |
| Shane Zylstra | 7 | 3 | 34 | 0 | 4.9 |
| Jermar Jefferson | 5 | 4 | 23 | 0 | 4.6 |
| Bobby Price | 1 | 1 | 17 | 0 | 17.0 |
| Jason Cabinda | 7 | 4 | 16 | 1 | 2.3 |
| Tyrell Williams | 3 | 2 | 14 | 0 | 4.7 |
| Taylor Decker | 2 | 2 | 4 | 1 | 2.0 |