Franchise 77 seasons 510–610–21 all-time 18 playoff trips 0 Super Bowls
2022 players
Passing
| Jared Goff | 587 | 382 | 4,438 | 29 | 7 | 7.6 |
| Jack Fox | 1 | 1 | 6 | 0 | 0 | 6.0 |
Rushing
| Jamaal Williams | 262 | 1,066 | 17 | 4.1 |
| D'Andre Swift | 99 | 542 | 5 | 5.5 |
| Justin Jackson | 42 | 170 | 1 | 4.0 |
| Craig Reynolds | 23 | 102 | 0 | 4.4 |
| Amon-Ra St. Brown | 9 | 95 | 0 | 10.6 |
| Jared Goff | 29 | 73 | 0 | 2.5 |
| C.J. Moore | 2 | 55 | 0 | 27.5 |
| Jameson Williams | 1 | 40 | 0 | 40.0 |
| Kalif Raymond | 7 | 36 | 0 | 5.1 |
| Jason Cabinda | 1 | 4 | 0 | 4.0 |
| Nate Sudfeld | 5 | -4 | 0 | -0.8 |
Receiving
| Amon-Ra St. Brown | 146 | 106 | 1,161 | 6 | 8.0 |
| Kalif Raymond | 64 | 47 | 616 | 0 | 9.6 |
| DJ Chark | 52 | 30 | 502 | 3 | 9.7 |
| Josh Reynolds | 59 | 38 | 479 | 3 | 8.1 |
| D'Andre Swift | 70 | 48 | 389 | 3 | 5.6 |
| Brock Wright | 24 | 18 | 216 | 4 | 9.0 |
| Tom Kennedy | 15 | 8 | 141 | 0 | 9.4 |
| Craig Reynolds | 10 | 9 | 116 | 0 | 11.6 |
| James Mitchell | 11 | 11 | 113 | 1 | 10.3 |
| Justin Jackson | 19 | 12 | 101 | 1 | 5.3 |
| Jamaal Williams | 16 | 12 | 73 | 0 | 4.6 |
| Shane Zylstra | 15 | 11 | 60 | 4 | 4.0 |
| Jameson Williams | 9 | 1 | 41 | 1 | 4.6 |
| Quintez Cephus | 3 | 2 | 15 | 0 | 5.0 |
| Penei Sewell | 1 | 1 | 9 | 0 | 9.0 |
| Maurice Alexander | 1 | 1 | 7 | 0 | 7.0 |
| Jared Goff | 1 | 1 | 5 | 0 | 5.0 |
| Jason Cabinda | 4 | 1 | 5 | 0 | 1.2 |
Defense
| Alex Anzalone | MLB | 98 | 50 | 1.5 | 1 | 6 | 1 |
| DeShon Elliott | SAF | 88 | 65 | 0.0 | 1 | 3 | 1 |
| Kerby Joseph | SAF | 76 | 49 | 0.0 | 4 | 8 | 2 |
| Malcolm Rodriguez | LB | 67 | 42 | 1.0 | 0 | 2 | 1 |
| Jeff Okudah | CB | 64 | 50 | 0.0 | 1 | 7 | 1 |
| Will Harris | SAF | 53 | 40 | 0.0 | 1 | 4 | 1 |
| Mike Hughes | CB | 47 | 31 | 0.0 | 0 | 1 | 0 |
| Aidan Hutchinson | DE | 46 | 28 | 9.5 | 3 | 3 | 0 |
| Isaiah Buggs | DT | 44 | 19 | 1.0 | 0 | 2 | 1 |
| Derrick Barnes | LB | 42 | 22 | 1.0 | 0 | 1 | 0 |
| Amani Oruwariye | CB | 41 | 33 | 0.0 | 0 | 3 | 0 |
| Alim McNeill | DT | 37 | 13 | 1.0 | 0 | 0 | 0 |
| Jerry Jacobs | CB | 35 | 30 | 1.0 | 1 | 8 | 0 |
| John Cominsky | DE | 30 | 18 | 4.0 | 0 | 3 | 1 |
| Chris Board | LB | 19 | 15 | 0.0 | 0 | 1 | 1 |
| JuJu Hughes | S | 18 | 14 | 1.0 | 0 | 0 | 0 |
| Tracy Walker III | DB | 17 | 8 | 1.0 | 0 | 1 | 0 |
| Julian Okwara | DE | 15 | 8 | 2.0 | 0 | 0 | 0 |
| Benito Jones | DT | 15 | 7 | 1.5 | 0 | 2 | 0 |
| Joshua Paschal | DE | 13 | 7 | 2.0 | 0 | 0 | 0 |
| Josh Woods | LB | 13 | 9 | 0.0 | 0 | 0 | 0 |
| Ifeatu Melifonwu | SAF | 13 | 8 | 0.5 | 0 | 2 | 0 |
| C.J. Moore | DB | 12 | 7 | 0.0 | 0 | 1 | 0 |
| Charles Harris | LB | 11 | 7 | 1.0 | 0 | 1 | 1 |
| James Houston | DE | 11 | 10 | 8.0 | 0 | 0 | 1 |
| AJ Parker | CB | 9 | 8 | 0.0 | 0 | 0 | 0 |
| Romeo Okwara | DE | 8 | 3 | 2.0 | 0 | 0 | 0 |
| Austin Bryant | DE | 7 | 5 | 0.0 | 0 | 1 | 0 |
| Bobby Price | DB | 4 | 3 | 0.0 | 0 | 0 | 0 |
| Michael Brockers | DT | 4 | 1 | 0.0 | 0 | 1 | 0 |
| Justin Jackson | RB | 4 | 2 | 0.0 | 0 | 0 | 0 |
| Anthony Pittman | LB | 4 | 2 | 0.0 | 0 | 0 | 1 |
| Chase Lucas | CB | 3 | 1 | 0.0 | 0 | 0 | 0 |
| Jared Goff | QB | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Tom Kennedy | WR | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Jason Cabinda | FB | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Quintez Cephus | WR | 2 | 2 | 0.0 | 0 | 0 | 0 |
| DJ Chark | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Dan Skipper | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Josh Reynolds | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Saivion Smith | S | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Jack Fox | P | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Penei Sewell | OT | 1 | 1 | 0.0 | 0 | 0 | 1 |
| Stanley Berryhill | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |