Franchise 25 seasons 175–218–1 all-time 9 playoff trips 0 Super Bowls
2005 players
Passing
| David Carr | 423 | 256 | 2,488 | 14 | 11 | 5.9 |
| Tony Banks | 25 | 14 | 173 | 1 | 2 | 6.9 |
| Domanick Williams | 1 | 0 | 0 | 0 | 0 | 0.0 |
Rushing
| Domanick Williams | 230 | 976 | 2 | 4.2 |
| Jonathan Wells | 90 | 325 | 4 | 3.6 |
| David Carr | 56 | 308 | 1 | 5.5 |
| Vernand Morency | 46 | 184 | 2 | 4.0 |
| Jabar Gaffney | 4 | 13 | 0 | 3.2 |
| Andre Johnson | 6 | 10 | 0 | 1.7 |
| Kris Brown | 1 | 4 | 0 | 4.0 |
| Chad Stanley | 1 | 0 | 0 | 0.0 |
| Corey Bradford | 1 | -2 | 0 | -2.0 |
| Tony Banks | 2 | -2 | 0 | -1.0 |
Receiving
| Andre Johnson | 63 | 688 | 2 | 10.9 |
| Jabar Gaffney | 55 | 492 | 2 | 8.9 |
| Corey Bradford | 34 | 436 | 5 | 12.8 |
| Domanick Williams | 39 | 337 | 4 | 8.6 |
| Jonathan Wells | 22 | 179 | 0 | 8.1 |
| Marcellus Rivers | 24 | 168 | 0 | 7.0 |
| Derick Armstrong | 9 | 115 | 0 | 12.8 |
| Vernand Morency | 10 | 87 | 0 | 8.7 |
| Jerome Mathis | 5 | 65 | 1 | 13.0 |
| Donovan Morgan | 4 | 42 | 0 | 10.5 |
| Matt Murphy | 2 | 26 | 0 | 13.0 |
| Mark Bruener | 2 | 22 | 0 | 11.0 |
| Moran Norris | 1 | 4 | 1 | 4.0 |
Defense
| Morlon Greenwood | OLB | 86 | 56 | 2.0 | 0 | 7 | 0 |
| Dunta Robinson | CB | 78 | 59 | 1.0 | 1 | 10 | 1 |
| DaShon Polk | LB | 71 | 41 | 2.5 | 0 | 1 | 1 |
| C.C. Brown | DB | 70 | 44 | 0.0 | 1 | 2 | 1 |
| Robaire Smith | DE | 59 | 34 | 1.5 | 0 | 4 | 0 |
| Marcus Coleman | DB | 43 | 37 | 0.0 | 1 | 3 | 1 |
| Antwan Peek | OLB | 43 | 26 | 6.0 | 0 | 2 | 2 |
| Shantee Orr | LB | 42 | 30 | 7.0 | 0 | 2 | 4 |
| Seth Payne | DT | 42 | 28 | 4.0 | 0 | 3 | 1 |
| Demarcus Faggins | DB | 41 | 33 | 0.0 | 0 | 6 | 0 |
| Jason Babin | DE | 33 | 22 | 4.0 | 0 | 2 | 2 |
| Phillip Buchanon | DB | 32 | 26 | 0.0 | 0 | 4 | 0 |
| Kailee Wong | LB | 30 | 18 | 1.0 | 0 | 0 | 0 |
| Glenn Earl | S | 30 | 17 | 0.0 | 2 | 6 | 0 |
| Lewis Sanders | DB | 27 | 23 | 0.0 | 1 | 3 | 1 |
| Gary Walker | DE | 25 | 15 | 2.0 | 0 | 4 | 2 |
| Troy Evans | OLB | 22 | 17 | 0.0 | 1 | 3 | 0 |
| Jason Simmons | DB | 20 | 14 | 1.0 | 0 | 1 | 1 |
| Junior Ioane | DE | 19 | 9 | 0.0 | 0 | 0 | 0 |
| Travis Johnson | DE | 18 | 15 | 1.0 | 0 | 0 | 0 |
| Charlie Anderson | LB | 14 | 10 | 1.0 | 0 | 2 | 0 |
| Ramon Walker | DB | 14 | 11 | 0.0 | 0 | 0 | 0 |
| Jerry DeLoach | DE | 10 | 7 | 1.0 | 0 | 0 | 0 |
| Jason Bell | DB | 10 | 9 | 0.0 | 0 | 4 | 1 |
| Alfred Malone | DE | 9 | 5 | 1.0 | 0 | 1 | 0 |
| Jonathan Wells | RB | 7 | 7 | 0.0 | 0 | 0 | 1 |
| Moran Norris | FB | 6 | 4 | 0.0 | 0 | 0 | 1 |
| Marcellus Rivers | TE | 6 | 6 | 0.0 | 0 | 0 | 0 |
| Bryan Pittman | LS | 5 | 2 | 0.0 | 0 | 0 | 0 |
| Chris McKenzie | DB | 3 | 3 | 1.0 | 0 | 2 | 0 |
| Frank Chamberlin | LB | 3 | 1 | 0.0 | 0 | 0 | 0 |
| Chad Stanley | P | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Corey Bradford | WR | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Matt Murphy | TE | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Jabar Gaffney | WR | 2 | 2 | 0.0 | 0 | 0 | 0 |
| David Carr | QB | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Kris Brown | K | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Mark Bruener | TE | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Fred Weary | G | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Todd Wade | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Chester Pitts | G | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Andre Johnson | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Milford Brown | G | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Jason Anderson | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Vernand Morency | RB | 1 | 0 | 0.0 | 0 | 0 | 0 |