Franchise 25 seasons 175–218–1 all-time 9 playoff trips 0 Super Bowls
2009 players
Passing
| Matt Schaub | 583 | 396 | 4,770 | 29 | 15 | 8.2 |
| Rex Grossman | 9 | 3 | 33 | 0 | 1 | 3.7 |
| Chris Brown | 1 | 0 | 0 | 0 | 1 | 0.0 |
Rushing
| Steve Slaton | 131 | 437 | 3 | 3.3 |
| Ryan Moats | 101 | 390 | 4 | 3.9 |
| Chris Brown | 79 | 267 | 3 | 3.4 |
| Arian Foster | 54 | 257 | 3 | 4.8 |
| Matt Schaub | 47 | 61 | 0 | 1.3 |
| Kevin Walter | 4 | 26 | 0 | 6.5 |
| Jacoby Jones | 3 | 22 | 0 | 7.3 |
| Andre Johnson | 2 | 10 | 0 | 5.0 |
| Rex Grossman | 3 | 5 | 0 | 1.7 |
Receiving
| Andre Johnson | 171 | 101 | 1,569 | 9 | 9.2 |
| Kevin Walter | 70 | 53 | 611 | 2 | 8.7 |
| Owen Daniels | 58 | 40 | 519 | 5 | 8.9 |
| Jacoby Jones | 40 | 27 | 437 | 6 | 10.9 |
| Steve Slaton | 55 | 44 | 417 | 4 | 7.6 |
| David Anderson | 53 | 38 | 370 | 0 | 7.0 |
| Joel Dreessen | 39 | 26 | 320 | 1 | 8.2 |
| Vonta Leach | 26 | 20 | 155 | 1 | 6.0 |
| Ryan Moats | 15 | 13 | 106 | 1 | 7.1 |
| Arian Foster | 9 | 8 | 93 | 0 | 10.3 |
| Chris Brown | 21 | 16 | 74 | 0 | 3.5 |
| James Casey | 12 | 6 | 64 | 0 | 5.3 |
| Andre Davis | 11 | 6 | 59 | 0 | 5.4 |
| Anthony Hill | 2 | 1 | 9 | 0 | 4.5 |
Defense
| Brian Cushing | ILB | 112 | 65 | 5.0 | 4 | 10 | 2 |
| DeMeco Ryans | ILB | 102 | 72 | 1.0 | 0 | 2 | 1 |
| Bernard Pollard | S | 85 | 66 | 1.5 | 4 | 7 | 0 |
| Dunta Robinson | CB | 57 | 47 | 0.0 | 0 | 9 | 1 |
| Glover Quin | FS | 54 | 42 | 0.0 | 0 | 11 | 0 |
| Zac Diles | LB | 51 | 34 | 0.0 | 0 | 1 | 2 |
| Mario Williams | DE | 36 | 31 | 9.0 | 0 | 3 | 2 |
| John Busing | FS | 29 | 23 | 0.0 | 1 | 3 | 0 |
| Dominique Barber | DB | 29 | 24 | 0.0 | 1 | 4 | 0 |
| Amobi Okoye | DT | 28 | 16 | 1.5 | 0 | 3 | 0 |
| Antonio Smith | DE | 27 | 20 | 4.0 | 0 | 1 | 2 |
| Jacques Reeves | CB | 26 | 20 | 0.0 | 1 | 7 | 0 |
| Eugene Wilson | FS | 22 | 17 | 0.0 | 2 | 3 | 1 |
| Kevin Bentley | LB | 19 | 8 | 0.0 | 0 | 0 | 0 |
| Jeff Zgonina | DT | 19 | 14 | 1.5 | 0 | 0 | 0 |
| Shaun Cody | NT | 16 | 8 | 1.0 | 0 | 1 | 0 |
| Tim Bulman | DT | 16 | 10 | 0.0 | 0 | 1 | 0 |
| Fred Bennett | DB | 16 | 13 | 0.0 | 0 | 1 | 0 |
| Connor Barwin | ILB | 15 | 9 | 3.5 | 0 | 4 | 0 |
| Brice McCain | CB | 14 | 13 | 0.0 | 1 | 3 | 0 |
| Brian Russell | DB | 14 | 9 | 0.0 | 0 | 0 | 0 |
| Glenn Martinez | WR | 8 | 5 | 0.0 | 0 | 0 | 0 |
| Xavier Adibi | LB | 8 | 6 | 0.0 | 0 | 0 | 1 |
| Nick Ferguson | FS | 7 | 5 | 0.0 | 0 | 1 | 0 |
| Chaun Thompson | LB | 5 | 3 | 0.0 | 0 | 0 | 0 |
| Andre Davis | WR | 5 | 3 | 0.0 | 0 | 0 | 0 |
| Ryan Moats | RB | 4 | 4 | 0.0 | 0 | 0 | 0 |
| Andre Johnson | WR | 4 | 4 | 0.0 | 0 | 0 | 0 |
| James Casey | TE | 4 | 3 | 0.0 | 0 | 0 | 0 |
| Joel Dreessen | TE | 4 | 2 | 0.0 | 0 | 0 | 0 |
| Duane Brown | OT | 3 | 3 | 0.0 | 0 | 0 | 0 |
| DelJuan Robinson | DT | 3 | 2 | 0.0 | 0 | 0 | 0 |
| David Anderson | WR | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Antwaun Molden | DB | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Jacoby Jones | WR | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Kevin Walter | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Kris Brown | K | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Khary Campbell | LB | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Chester Pitts | G | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Eric Winston | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Owen Daniels | TE | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Chris White | G | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Chris Myers | C | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Matt Schaub | QB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Kasey Studdard | G | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Tim Jamison | NT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Arian Foster | RB | 1 | 0 | 0.0 | 0 | 0 | 0 |