Franchise 25 seasons 175–218–1 all-time 9 playoff trips 0 Super Bowls
2010 players
Passing
| Matt Schaub | 574 | 365 | 4,370 | 24 | 12 | 7.6 |
Rushing
| Arian Foster | 326 | 1,614 | 16 | 5.0 |
| Derrick Ward | 51 | 317 | 4 | 6.2 |
| Steve Slaton | 19 | 93 | 0 | 4.9 |
| Matt Schaub | 22 | 28 | 0 | 1.3 |
| Andre Johnson | 2 | 10 | 0 | 5.0 |
| Jacoby Jones | 2 | 7 | 0 | 3.5 |
| Matt Turk | 1 | -27 | 0 | -27.0 |
Receiving
| Andre Johnson | 138 | 86 | 1,216 | 8 | 8.8 |
| Kevin Walter | 80 | 51 | 621 | 5 | 7.8 |
| Arian Foster | 84 | 66 | 604 | 2 | 7.2 |
| Jacoby Jones | 78 | 51 | 562 | 3 | 7.2 |
| Joel Dreessen | 55 | 36 | 518 | 4 | 9.4 |
| Owen Daniels | 68 | 38 | 471 | 2 | 6.9 |
| David Anderson | 18 | 11 | 117 | 0 | 6.5 |
| James Casey | 14 | 8 | 98 | 0 | 7.0 |
| Vonta Leach | 15 | 8 | 91 | 0 | 6.1 |
| Derrick Ward | 11 | 7 | 61 | 0 | 5.5 |
| Steve Slaton | 4 | 3 | 11 | 0 | 2.8 |
Defense
| Bernard Pollard | S | 94 | 64 | 2.5 | 0 | 5 | 4 |
| Glover Quin | FS | 76 | 62 | 0.0 | 3 | 14 | 1 |
| Zac Diles | LB | 64 | 41 | 0.0 | 0 | 0 | 0 |
| Brian Cushing | ILB | 60 | 37 | 1.5 | 0 | 4 | 1 |
| Jason Allen | DB | 57 | 44 | 0.0 | 6 | 12 | 0 |
| Kareem Jackson | S | 56 | 43 | 0.0 | 2 | 10 | 0 |
| Eugene Wilson | FS | 53 | 38 | 0.0 | 0 | 3 | 0 |
| DeMeco Ryans | ILB | 44 | 22 | 1.0 | 0 | 2 | 0 |
| Troy Nolan | DB | 42 | 30 | 1.0 | 3 | 5 | 0 |
| Kevin Bentley | LB | 40 | 20 | 0.0 | 1 | 1 | 0 |
| Amobi Okoye | DT | 35 | 18 | 3.0 | 0 | 0 | 0 |
| Darryl Sharpton | ILB | 31 | 20 | 1.0 | 0 | 0 | 0 |
| Antonio Smith | DE | 31 | 16 | 4.0 | 0 | 2 | 1 |
| Shaun Cody | NT | 29 | 12 | 0.0 | 0 | 0 | 0 |
| Mario Williams | DE | 27 | 21 | 8.5 | 0 | 2 | 1 |
| Earl Mitchell | DT | 24 | 14 | 1.0 | 0 | 0 | 0 |
| Brice McCain | CB | 21 | 16 | 0.0 | 0 | 2 | 0 |
| Mark Anderson | DE | 20 | 15 | 4.0 | 0 | 2 | 0 |
| Xavier Adibi | LB | 18 | 12 | 0.0 | 0 | 0 | 1 |
| James Casey | TE | 15 | 8 | 0.0 | 0 | 0 | 0 |
| Tim Jamison | NT | 12 | 9 | 1.0 | 0 | 0 | 0 |
| Damione Lewis | DT | 11 | 7 | 1.0 | 0 | 1 | 0 |
| Sherrick McManis | DB | 11 | 7 | 0.0 | 1 | 1 | 0 |
| Jesse Nading | LB | 10 | 5 | 0.5 | 0 | 1 | 0 |
| Neil Rackers | K | 8 | 4 | 0.0 | 0 | 0 | 0 |
| Joel Dreessen | TE | 7 | 7 | 0.0 | 0 | 0 | 0 |
| David Nixon | LB | 6 | 4 | 0.0 | 0 | 0 | 0 |
| Antwaun Molden | DB | 6 | 5 | 0.0 | 0 | 0 | 0 |
| Vonta Leach | FB | 5 | 3 | 0.0 | 0 | 0 | 0 |
| Dominique Barber | DB | 4 | 3 | 0.0 | 0 | 0 | 0 |
| Stanford Keglar | LB | 3 | 2 | 0.0 | 0 | 0 | 0 |
| Jon Weeks | LS | 3 | 1 | 0.0 | 0 | 0 | 0 |
| David Anderson | WR | 2 | 2 | 0.0 | 0 | 0 | 1 |
| Garrett Graham | TE | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Chris Myers | C | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Kevin Walter | WR | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Adewale Ogunleye | DE | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Andre Johnson | WR | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Karl Paymah | DB | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Steve Slaton | RB | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Wade Smith | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Matt Turk | P | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Matt Schaub | QB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Quintin Demps | S | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Duane Brown | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Owen Daniels | TE | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Arian Foster | RB | 1 | 1 | 0.0 | 0 | 0 | 1 |