Franchise 25 seasons 175–218–1 all-time 9 playoff trips 0 Super Bowls
2012 players
Passing
| Matt Schaub | 544 | 350 | 4,008 | 22 | 12 | 7.4 |
| T.J. Yates | 10 | 4 | 38 | 0 | 1 | 3.8 |
Rushing
| Arian Foster | 351 | 1,424 | 15 | 4.1 |
| Justin Forsett | 63 | 374 | 1 | 5.9 |
| Ben Tate | 65 | 279 | 2 | 4.3 |
| Keshawn Martin | 4 | 53 | 0 | 13.2 |
| James Casey | 1 | 6 | 0 | 6.0 |
| T.J. Yates | 2 | -1 | 1 | -0.5 |
| DeVier Posey | 1 | -3 | 0 | -3.0 |
| Matt Schaub | 21 | -9 | 0 | -0.4 |
Receiving
| Andre Johnson | 163 | 112 | 1,598 | 4 | 9.8 |
| Owen Daniels | 104 | 62 | 716 | 6 | 6.9 |
| Kevin Walter | 68 | 41 | 518 | 2 | 7.6 |
| James Casey | 44 | 34 | 330 | 3 | 7.5 |
| Garrett Graham | 40 | 28 | 263 | 3 | 6.6 |
| Arian Foster | 58 | 40 | 217 | 2 | 3.7 |
| Lestar Jean | 12 | 6 | 151 | 1 | 12.6 |
| DeVier Posey | 14 | 6 | 87 | 0 | 6.2 |
| Keshawn Martin | 28 | 10 | 85 | 1 | 3.0 |
| Ben Tate | 11 | 11 | 49 | 0 | 4.5 |
| Justin Forsett | 5 | 3 | 38 | 0 | 7.6 |
| Matt Schaub | 1 | 1 | -6 | 0 | -6.0 |
Defense
| J.J. Watt | DE | 80 | 68 | 20.5 | 0 | 16 | 4 |
| Glover Quin | FS | 79 | 59 | 1.0 | 2 | 13 | 2 |
| Danieal Manning | S | 72 | 54 | 1.0 | 2 | 8 | 3 |
| Bradie James | ILB | 71 | 40 | 0.5 | 0 | 2 | 0 |
| Johnathan Joseph | CB | 56 | 51 | 0.0 | 2 | 10 | 0 |
| Kareem Jackson | S | 53 | 47 | 0.0 | 4 | 17 | 0 |
| Tim Dobbins | LB | 43 | 30 | 0.0 | 1 | 4 | 0 |
| Connor Barwin | ILB | 40 | 31 | 3.0 | 0 | 6 | 0 |
| Quintin Demps | S | 36 | 27 | 0.0 | 0 | 5 | 0 |
| Earl Mitchell | DT | 30 | 18 | 0.0 | 0 | 3 | 1 |
| Darryl Sharpton | ILB | 28 | 16 | 0.0 | 1 | 1 | 0 |
| Brian Cushing | ILB | 27 | 20 | 0.0 | 1 | 2 | 1 |
| Antonio Smith | DE | 27 | 20 | 7.0 | 0 | 3 | 2 |
| Brooks Reed | LB | 27 | 19 | 2.5 | 0 | 3 | 1 |
| Whitney Mercilus | DE | 23 | 18 | 6.0 | 0 | 1 | 2 |
| Jared Crick | DE | 22 | 13 | 0.0 | 0 | 2 | 0 |
| Bryan Braman | LB | 21 | 17 | 0.0 | 0 | 0 | 0 |
| Brice McCain | CB | 21 | 17 | 0.5 | 1 | 8 | 0 |
| Alan Ball | CB | 21 | 18 | 0.0 | 0 | 3 | 1 |
| Stanford Routt | CB | 21 | 19 | 0.0 | 2 | 4 | 1 |
| Barrett Ruud | ILB | 16 | 12 | 1.0 | 0 | 1 | 0 |
| Shaun Cody | NT | 15 | 8 | 0.0 | 0 | 2 | 0 |
| Brandon Harris | DB | 14 | 10 | 0.0 | 0 | 3 | 0 |
| Shiloh Keo | DB | 14 | 9 | 0.0 | 1 | 1 | 0 |
| Jesse Nading | LB | 12 | 9 | 0.0 | 0 | 0 | 0 |
| Troy Nolan | DB | 8 | 5 | 0.0 | 0 | 0 | 0 |
| Roc Carmichael | DB | 8 | 7 | 0.0 | 0 | 1 | 0 |
| DeVier Posey | WR | 6 | 2 | 0.0 | 0 | 0 | 0 |
| Justin Forsett | RB | 5 | 5 | 0.0 | 0 | 0 | 0 |
| Owen Daniels | TE | 4 | 4 | 0.0 | 0 | 0 | 0 |
| James Casey | TE | 4 | 4 | 0.0 | 0 | 0 | 0 |
| Mister Alexander | LB | 4 | 3 | 0.0 | 0 | 0 | 0 |
| Garrett Graham | TE | 4 | 4 | 0.0 | 0 | 0 | 0 |
| Tim Jamison | NT | 3 | 2 | 1.0 | 0 | 1 | 0 |
| Shayne Graham | K | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Donnie Jones | P | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Andre Johnson | WR | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Jon Weeks | LS | 2 | 0 | 0.0 | 0 | 0 | 0 |
| Keshawn Martin | WR | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Kevin Walter | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Arian Foster | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Antoine Caldwell | G | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Tyler Clutts | FB | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Derek Newton | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Eddie Pleasant | DB | 1 | 1 | 0.0 | 0 | 0 | 0 |