Franchise 76 seasons 584–547–10 all-time 29 playoff trips 2 Super Bowls
2005 players
Passing
| Peyton Manning | 453 | 305 | 3,747 | 28 | 10 | 8.3 |
| Jim Sorgi | 62 | 43 | 444 | 3 | 1 | 7.2 |
| Hunter Smith | 1 | 0 | 0 | 0 | 0 | 0.0 |
Rushing
| Edgerrin James | 360 | 1,506 | 13 | 4.2 |
| Dominic Rhodes | 40 | 118 | 4 | 3.0 |
| Peyton Manning | 33 | 45 | 0 | 1.4 |
| Ran Carthon | 13 | 18 | 1 | 1.4 |
| James Mungro | 7 | 15 | 0 | 2.1 |
| Jim Sorgi | 12 | 1 | 0 | 0.1 |
Receiving
| Marvin Harrison | 82 | 1,146 | 12 | 14.0 |
| Reggie Wayne | 83 | 1,055 | 5 | 12.7 |
| Brandon Stokley | 41 | 543 | 1 | 13.2 |
| Dallas Clark | 37 | 488 | 4 | 13.2 |
| Edgerrin James | 44 | 337 | 1 | 7.7 |
| Bryan Fletcher | 18 | 202 | 3 | 11.2 |
| Troy Walters | 14 | 152 | 3 | 10.9 |
| Dominic Rhodes | 13 | 88 | 0 | 6.8 |
| Aaron Moorehead | 7 | 75 | 0 | 10.7 |
| Ben Utecht | 3 | 59 | 2 | 19.7 |
| James Mungro | 3 | 28 | 0 | 9.3 |
| Ran Carthon | 1 | 10 | 0 | 10.0 |
| Ben Hartsock | 2 | 8 | 0 | 4.0 |
Defense
| Gary Brackett | MLB | 90 | 55 | 1.0 | 3 | 6 | 0 |
| Bob Sanders | S | 81 | 61 | 0.0 | 1 | 4 | 1 |
| Cato June | LB | 80 | 45 | 0.0 | 5 | 7 | 0 |
| David Thornton | OLB | 66 | 44 | 2.0 | 0 | 1 | 2 |
| Nick Harper | CB | 57 | 51 | 0.0 | 3 | 15 | 0 |
| Mike Doss | DB | 57 | 37 | 0.0 | 2 | 5 | 0 |
| Robert Mathis | OLB | 51 | 41 | 11.0 | 0 | 2 | 8 |
| Marlin Jackson | DB | 46 | 31 | 0.0 | 1 | 4 | 0 |
| Raheem Brock | DE | 34 | 25 | 5.5 | 0 | 2 | 4 |
| Jason David | DB | 33 | 22 | 0.0 | 2 | 10 | 0 |
| Gerome Sapp | DB | 31 | 22 | 0.0 | 0 | 0 | 0 |
| Dwight Freeney | DE | 31 | 27 | 10.5 | 0 | 3 | 6 |
| Montae Reagor | DE | 29 | 20 | 6.5 | 0 | 0 | 0 |
| Keith O'Neil | LB | 28 | 20 | 0.0 | 0 | 0 | 1 |
| Corey Simon | DT | 27 | 18 | 0.0 | 0 | 2 | 1 |
| Rob Morris | LB | 25 | 18 | 0.0 | 0 | 2 | 0 |
| Larry Tripplett | DT | 24 | 19 | 4.0 | 0 | 2 | 1 |
| Kelvin Hayden | DB | 18 | 10 | 0.0 | 0 | 1 | 0 |
| Gilbert Gardner | LB | 17 | 9 | 1.0 | 1 | 2 | 0 |
| Josh Thomas | DE | 16 | 7 | 2.5 | 0 | 0 | 0 |
| Matt Giordano | FS | 8 | 6 | 0.0 | 0 | 1 | 0 |
| Dexter Reid | DB | 8 | 6 | 0.0 | 0 | 0 | 1 |
| Darrell Reid | DE | 8 | 4 | 0.0 | 0 | 0 | 0 |
| Joseph Jefferson | CB | 8 | 4 | 0.0 | 0 | 0 | 0 |
| Mike Labinjo | LB | 8 | 8 | 1.0 | 0 | 0 | 1 |
| Josh Williams | DT | 5 | 2 | 0.0 | 0 | 0 | 1 |
| Von Hutchins | DB | 5 | 3 | 0.0 | 0 | 0 | 0 |
| Bryan Fletcher | TE | 4 | 3 | 0.0 | 0 | 0 | 0 |
| Dallas Clark | TE | 4 | 4 | 0.0 | 0 | 0 | 1 |
| Jonathan Welsh | DE | 3 | 1 | 0.0 | 0 | 0 | 0 |
| Brandon Stokley | WR | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Marvin Harrison | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Hunter Smith | P | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Edgerrin James | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Peyton Manning | QB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Jeff Saturday | C | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Dominic Rhodes | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Ryan Diem | G | 1 | 1 | 0.0 | 0 | 0 | 0 |
| James Mungro | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Ben Hartsock | TE | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Jake Scott | G | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Dave Rayner | K | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Johnathan Goddard | LB | 1 | 1 | 0.0 | 0 | 0 | 0 |