Franchise 58 seasons 473–417–7 all-time 23 playoff trips 3 Super Bowls
2005 players
Passing
| Trent Green | 507 | 317 | 4,014 | 17 | 10 | 7.9 |
Rushing
| Larry Johnson | 336 | 1,750 | 20 | 5.2 |
| Priest Holmes | 119 | 451 | 6 | 3.8 |
| Trent Green | 35 | 82 | 0 | 2.3 |
| Eddie Kennison | 7 | 43 | 0 | 6.1 |
| Dee Brown | 7 | 21 | 0 | 3.0 |
| Tony Richardson | 6 | 20 | 0 | 3.3 |
| Dante Hall | 7 | 11 | 0 | 1.6 |
| Kris Wilson | 1 | 6 | 0 | 6.0 |
| Todd Collins | 2 | -2 | 0 | -1.0 |
Receiving
| Eddie Kennison | 68 | 1,102 | 5 | 16.2 |
| Tony Gonzalez | 78 | 905 | 2 | 11.6 |
| Samie Parker | 36 | 533 | 3 | 14.8 |
| Dante Hall | 34 | 436 | 3 | 12.8 |
| Larry Johnson | 33 | 343 | 1 | 10.4 |
| Priest Holmes | 21 | 197 | 1 | 9.4 |
| Chris Horn | 18 | 187 | 0 | 10.4 |
| Marc Boerigter | 8 | 119 | 0 | 14.9 |
| Tony Richardson | 9 | 68 | 1 | 7.6 |
| Jason Dunn | 5 | 53 | 0 | 10.6 |
| Kris Wilson | 3 | 33 | 0 | 11.0 |
| Dee Brown | 3 | 23 | 1 | 7.7 |
| Ronnie Cruz | 1 | 15 | 0 | 15.0 |
Defense
| Derrick Johnson | LB | 89 | 73 | 2.0 | 0 | 5 | 2 |
| Kawika Mitchell | OLB | 84 | 63 | 1.0 | 1 | 11 | 0 |
| Sammy Knight | DB | 82 | 62 | 2.5 | 2 | 13 | 2 |
| Greg Wesley | FS | 71 | 54 | 0.0 | 6 | 8 | 1 |
| Patrick Surtain | CB | 53 | 43 | 0.0 | 4 | 12 | 0 |
| Eric Warfield | CB | 52 | 48 | 0.0 | 1 | 9 | 0 |
| Jared Allen | DE | 49 | 42 | 11.0 | 0 | 5 | 6 |
| Eric Hicks | DE | 37 | 28 | 3.5 | 0 | 2 | 2 |
| Benny Sapp | CB | 37 | 31 | 2.5 | 0 | 5 | 2 |
| Kendrell Bell | OLB | 31 | 22 | 1.5 | 0 | 0 | 0 |
| John Browning | DT | 30 | 26 | 2.0 | 0 | 4 | 1 |
| Rich Scanlon | LB | 24 | 20 | 0.0 | 0 | 0 | 0 |
| Jimmy Wilkerson | DE | 20 | 18 | 0.0 | 0 | 2 | 0 |
| Dexter McCleon | DB | 19 | 18 | 0.0 | 2 | 7 | 0 |
| Lional Dalton | DT | 16 | 10 | 1.0 | 0 | 0 | 0 |
| Gary Stills | LB | 16 | 11 | 0.0 | 0 | 1 | 0 |
| Dewayne Washington | DB | 14 | 13 | 0.0 | 0 | 2 | 1 |
| Boomer Grigsby | LB | 14 | 10 | 0.0 | 0 | 0 | 0 |
| Carlos Hall | DE | 13 | 10 | 1.0 | 0 | 4 | 2 |
| Chris Horn | WR | 8 | 8 | 0.0 | 0 | 0 | 0 |
| Ryan Sims | DE | 7 | 7 | 0.0 | 0 | 0 | 0 |
| Ronnie Cruz | RB | 6 | 5 | 0.0 | 0 | 0 | 0 |
| William Bartee | DB | 5 | 4 | 0.0 | 0 | 0 | 0 |
| Junior Siavii | DT | 4 | 3 | 0.0 | 0 | 0 | 0 |
| Kris Griffin | LB | 4 | 4 | 0.0 | 0 | 0 | 0 |
| Dante Hall | WR | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Kris Wilson | TE | 3 | 2 | 0.0 | 0 | 0 | 0 |
| Dustin Colquitt | P | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Keyaron Fox | LB | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Eddie Kennison | WR | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Will Shields | G | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Tony Gonzalez | TE | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Jerome Woods | FS | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Dee Brown | RB | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Larry Johnson | RB | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Trent Green | QB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Jason Dunn | TE | 1 | 1 | 0.0 | 0 | 0 | 0 |
| John Welbourn | G | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Brian Waters | G | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Marc Boerigter | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Lawrence Tynes | K | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Jordan Black | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Samie Parker | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |