Franchise 58 seasons 473–417–7 all-time 23 playoff trips 3 Super Bowls
2006 players
Passing
| Damon Huard | 244 | 148 | 1,878 | 11 | 1 | 7.7 |
| Trent Green | 198 | 121 | 1,342 | 7 | 9 | 6.8 |
| Brodie Croyle | 7 | 3 | 23 | 0 | 2 | 3.3 |
| Larry Johnson | 1 | 0 | 0 | 0 | 0 | 0.0 |
Rushing
| Larry Johnson | 416 | 1,789 | 17 | 4.3 |
| Michael Bennett | 36 | 200 | 0 | 5.6 |
| Trent Green | 19 | 59 | 0 | 3.1 |
| Dee Brown | 10 | 24 | 0 | 2.4 |
| Ronnie Cruz | 5 | 19 | 0 | 3.8 |
| Eddie Kennison | 4 | 16 | 0 | 4.0 |
| Dante Hall | 3 | 11 | 0 | 3.7 |
| Damon Huard | 9 | 9 | 0 | 1.0 |
| Derrick Ross | 3 | 8 | 0 | 2.7 |
| Samie Parker | 3 | 7 | 0 | 2.3 |
| Jarrad Page | 1 | 4 | 0 | 4.0 |
| Dustin Colquitt | 1 | 0 | 0 | 0.0 |
| Brodie Croyle | 3 | -3 | 0 | -1.0 |
Receiving
| Tony Gonzalez | 73 | 900 | 5 | 12.3 |
| Eddie Kennison | 53 | 860 | 5 | 16.2 |
| Samie Parker | 41 | 561 | 1 | 13.7 |
| Larry Johnson | 41 | 410 | 2 | 10.0 |
| Dante Hall | 26 | 204 | 2 | 7.8 |
| Kris Wilson | 15 | 132 | 3 | 8.8 |
| Michael Bennett | 9 | 77 | 0 | 8.6 |
| Jason Dunn | 4 | 40 | 0 | 10.0 |
| Jeff Webb | 3 | 23 | 0 | 7.7 |
| Ronnie Cruz | 2 | 20 | 0 | 10.0 |
| Rod Gardner | 2 | 17 | 0 | 8.5 |
| Dee Brown | 1 | 5 | 0 | 5.0 |
| Damon Huard | 2 | -6 | 0 | -3.0 |
Defense
| Kawika Mitchell | OLB | 84 | 63 | 2.0 | 1 | 3 | 1 |
| Jared Allen | DE | 72 | 61 | 8.0 | 1 | 10 | 5 |
| Sammy Knight | DB | 70 | 61 | 2.0 | 1 | 4 | 0 |
| Derrick Johnson | LB | 66 | 48 | 2.5 | 0 | 2 | 1 |
| Ty Law | CB | 62 | 58 | 1.0 | 4 | 9 | 3 |
| Patrick Surtain | CB | 59 | 51 | 1.0 | 1 | 6 | 3 |
| Tamba Hali | OLB | 57 | 41 | 7.5 | 1 | 4 | 4 |
| Greg Wesley | FS | 56 | 51 | 1.0 | 3 | 7 | 1 |
| Kendrell Bell | OLB | 46 | 40 | 1.0 | 0 | 0 | 0 |
| Keyaron Fox | LB | 43 | 35 | 1.0 | 0 | 1 | 0 |
| Jarrad Page | S | 34 | 29 | 1.0 | 3 | 8 | 0 |
| James Reed | DT | 33 | 26 | 1.0 | 0 | 2 | 0 |
| Lenny Walls | CB | 26 | 25 | 0.0 | 0 | 4 | 1 |
| Jimmy Wilkerson | DE | 22 | 17 | 0.0 | 0 | 2 | 0 |
| Ron Edwards | DT | 18 | 14 | 2.0 | 0 | 1 | 0 |
| Kris Griffin | LB | 15 | 12 | 0.0 | 0 | 0 | 0 |
| Benny Sapp | CB | 15 | 14 | 0.0 | 0 | 0 | 0 |
| Dee Brown | RB | 11 | 8 | 0.0 | 0 | 0 | 0 |
| Bernard Pollard | S | 11 | 11 | 0.0 | 0 | 1 | 1 |
| Boomer Grigsby | LB | 10 | 10 | 0.0 | 0 | 0 | 0 |
| Rich Scanlon | LB | 9 | 7 | 0.0 | 0 | 0 | 0 |
| Derrick Ross | RB | 6 | 6 | 0.0 | 0 | 0 | 1 |
| Jeff Webb | WR | 6 | 5 | 0.0 | 0 | 0 | 0 |
| Ryan Sims | DE | 6 | 3 | 0.0 | 0 | 0 | 0 |
| Eric Hicks | DE | 6 | 1 | 0.0 | 0 | 0 | 0 |
| Rod Gardner | WR | 4 | 4 | 0.0 | 0 | 0 | 1 |
| Eddie Kennison | WR | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Steve Williams | DT | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Kendall Gammon | LS | 3 | 2 | 0.0 | 0 | 0 | 0 |
| Larry Johnson | RB | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Lawrence Tynes | K | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Tony Gonzalez | TE | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Kevin Sampson | OT | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Brian Waters | G | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Trent Green | QB | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Casey Wiegmann | C | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Damon Huard | QB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Ronnie Cruz | RB | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Michael Bennett | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Michael Bragg | DB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Samie Parker | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Kris Wilson | TE | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Dustin Colquitt | P | 1 | 1 | 0.0 | 0 | 0 | 0 |