Franchise 58 seasons 473–417–7 all-time 23 playoff trips 3 Super Bowls
2008 players
Passing
| Tyler Thigpen | 420 | 230 | 2,608 | 18 | 12 | 6.2 |
| Damon Huard | 81 | 50 | 477 | 2 | 4 | 5.9 |
| Brodie Croyle | 29 | 20 | 151 | 0 | 0 | 5.2 |
| Quinn Gray | 8 | 7 | 76 | 1 | 0 | 9.5 |
| Mark Bradley | 1 | 1 | 37 | 1 | 0 | 37.0 |
| Marques Hagans | 1 | 1 | 5 | 0 | 0 | 5.0 |
| Larry Johnson | 1 | 1 | 4 | 1 | 0 | 4.0 |
Rushing
| Larry Johnson | 193 | 874 | 5 | 4.5 |
| Tyler Thigpen | 62 | 386 | 3 | 6.2 |
| Jamaal Charles | 67 | 357 | 0 | 5.3 |
| Kolby Smith | 35 | 100 | 1 | 2.9 |
| Dantrell Savage | 15 | 53 | 0 | 3.5 |
| Quinn Gray | 1 | 27 | 0 | 27.0 |
| Damon Huard | 4 | 13 | 0 | 3.2 |
| Marques Hagans | 1 | 2 | 0 | 2.0 |
| Mike Cox | 1 | -2 | 0 | -2.0 |
Receiving
| Tony Gonzalez | 96 | 1,058 | 10 | 11.0 |
| Dwayne Bowe | 86 | 1,022 | 7 | 11.9 |
| Mark Bradley | 30 | 380 | 3 | 12.7 |
| Jamaal Charles | 27 | 272 | 1 | 10.1 |
| Devard Darling | 17 | 247 | 1 | 14.5 |
| Will Franklin | 7 | 83 | 0 | 11.9 |
| Larry Johnson | 12 | 74 | 0 | 6.2 |
| Brad Cottam | 7 | 63 | 0 | 9.0 |
| Kolby Smith | 10 | 52 | 0 | 5.2 |
| Jeff Webb | 5 | 46 | 0 | 9.2 |
| Tyler Thigpen | 1 | 37 | 1 | 37.0 |
| Mike Cox | 8 | 19 | 0 | 2.4 |
| Marques Hagans | 1 | 7 | 0 | 7.0 |
| Dantrell Savage | 2 | 0 | 0 | 0.0 |
| Jackie Battle | 1 | -2 | 0 | -2.0 |