Franchise 58 seasons 473–417–7 all-time 23 playoff trips 3 Super Bowls
2009 players
Passing
| Matt Cassel | 494 | 272 | 2,924 | 16 | 16 | 5.9 |
| Brodie Croyle | 40 | 23 | 230 | 2 | 0 | 5.8 |
| Mark Bradley | 1 | 1 | 26 | 0 | 0 | 26.0 |
| Matt Gutierrez | 1 | 1 | 3 | 0 | 0 | 3.0 |
| Tim Castille | 1 | 0 | 0 | 0 | 1 | 0.0 |
Rushing
| Jamaal Charles | 190 | 1,120 | 7 | 5.9 |
| Matt Cassel | 50 | 196 | 0 | 3.9 |
| Tim Castille | 14 | 55 | 0 | 3.9 |
| Dantrell Savage | 10 | 45 | 0 | 4.5 |
| Quinten Lawrence | 2 | 42 | 0 | 21.0 |
| Kolby Smith | 15 | 33 | 0 | 2.2 |
| Jackie Battle | 7 | 21 | 0 | 3.0 |
| Mark Bradley | 2 | 20 | 0 | 10.0 |
| Bobby Wade | 2 | 11 | 0 | 5.5 |
| Javarris Williams | 6 | 6 | 0 | 1.0 |
| Mike Cox | 3 | 5 | 1 | 1.7 |
| Jon McGraw | 1 | 4 | 0 | 4.0 |
| Dustin Colquitt | 1 | 0 | 0 | 0.0 |
| Lance Long | 1 | -1 | 0 | -1.0 |
Receiving
| Chris Chambers | 92 | 45 | 730 | 5 | 7.9 |
| Dwayne Bowe | 87 | 47 | 589 | 4 | 6.8 |
| Bobby Wade | 75 | 37 | 367 | 2 | 4.9 |
| Mark Bradley | 57 | 24 | 320 | 2 | 5.6 |
| Jamaal Charles | 56 | 40 | 297 | 1 | 5.3 |
| Lance Long | 38 | 20 | 178 | 0 | 4.7 |
| Leonard Pope | 30 | 20 | 174 | 1 | 5.8 |
| Sean Ryan | 27 | 14 | 135 | 2 | 5.0 |
| Brad Cottam | 15 | 9 | 120 | 0 | 8.0 |
| Mike Cox | 13 | 10 | 79 | 0 | 6.1 |
| Terrance Copper | 6 | 4 | 68 | 0 | 11.3 |
| Bobby Engram | 10 | 5 | 61 | 0 | 6.1 |
| Dantrell Savage | 11 | 7 | 51 | 0 | 4.6 |
| Tim Castille | 6 | 4 | 37 | 1 | 6.2 |
| Kolby Smith | 2 | 2 | 9 | 0 | 4.5 |
| Quinten Lawrence | 2 | 1 | 9 | 0 | 4.5 |
| Jake O'Connell | 10 | 2 | 7 | 0 | 0.7 |
| Mike Vrabel | 1 | 1 | 1 | 1 | 1.0 |
| Jackie Battle | 2 | 2 | -3 | 0 | -1.5 |
Defense
| Demorrio Williams | ILB | 98 | 76 | 0.0 | 0 | 6 | 0 |
| Mike Brown | S | 87 | 63 | 2.0 | 3 | 3 | 0 |
| Corey Mays | ILB | 72 | 53 | 0.0 | 0 | 2 | 0 |
| Brandon Flowers | CB | 61 | 54 | 0.0 | 5 | 23 | 2 |
| Brandon Carr | CB | 59 | 53 | 0.0 | 1 | 19 | 1 |
| Tamba Hali | OLB | 56 | 41 | 8.5 | 0 | 1 | 4 |
| Mike Vrabel | OLB | 47 | 38 | 2.0 | 0 | 6 | 2 |
| Jon McGraw | S | 42 | 38 | 1.0 | 1 | 1 | 0 |
| Glenn Dorsey | NT | 41 | 28 | 1.0 | 0 | 2 | 0 |
| Jovan Belcher | ILB | 38 | 36 | 0.0 | 0 | 1 | 0 |
| Derrick Johnson | LB | 32 | 24 | 1.5 | 3 | 5 | 1 |
| Tyson Jackson | DE | 32 | 21 | 0.0 | 0 | 2 | 0 |
| Andy Studebaker | LB | 26 | 21 | 0.5 | 2 | 3 | 1 |
| Ron Edwards | DT | 21 | 16 | 0.0 | 0 | 3 | 0 |
| Travis Daniels | DB | 20 | 16 | 0.0 | 0 | 2 | 0 |
| Wallace Gilberry | DE | 19 | 17 | 4.5 | 0 | 0 | 0 |
| DaJuan Morgan | DB | 18 | 18 | 0.0 | 0 | 0 | 0 |
| Maurice Leggett | CB | 16 | 15 | 0.0 | 0 | 5 | 0 |
| Jarrad Page | S | 16 | 16 | 0.0 | 0 | 2 | 1 |
| Terrance Copper | WR | 14 | 12 | 0.0 | 0 | 0 | 0 |
| Mike Richardson | DB | 13 | 11 | 0.0 | 0 | 0 | 0 |
| Alex Magee | DE | 8 | 6 | 2.0 | 0 | 0 | 0 |
| Jamaal Charles | RB | 6 | 6 | 0.0 | 0 | 0 | 0 |
| David Herron | LB | 5 | 4 | 0.0 | 0 | 0 | 0 |
| Tim Castille | FB | 5 | 5 | 0.0 | 0 | 0 | 0 |
| Donald Washington | S | 5 | 5 | 0.0 | 0 | 0 | 0 |
| Thomas Gafford | LS | 4 | 3 | 0.0 | 0 | 0 | 0 |
| Chris Chambers | WR | 4 | 4 | 0.0 | 0 | 0 | 0 |
| Wade Smith | OT | 4 | 4 | 0.0 | 0 | 0 | 0 |
| Matt Cassel | QB | 4 | 4 | 0.0 | 0 | 0 | 0 |
| Kenny Smith | DT | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Jackie Battle | RB | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Quinten Lawrence | DB | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Ricardo Colclough | DB | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Ricky Price | DB | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Dustin Colquitt | P | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Brian Waters | G | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Mark Bradley | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Lance Long | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Mike Cox | FB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Justin Rogers | LB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Leonard Pope | TE | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Dantrell Savage | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Branden Albert | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Ryan Succop | K | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Dion Gales | DE | 1 | 1 | 0.0 | 0 | 0 | 0 |