Franchise 58 seasons 473–417–7 all-time 23 playoff trips 3 Super Bowls
2014 players
Passing
| Alex Smith | 464 | 303 | 3,265 | 18 | 6 | 7.0 |
| Chase Daniel | 28 | 16 | 157 | 0 | 0 | 5.6 |
| Dustin Colquitt | 1 | 1 | 6 | 0 | 0 | 6.0 |
Rushing
| Jamaal Charles | 206 | 1,033 | 9 | 5.0 |
| Knile Davis | 134 | 463 | 6 | 3.5 |
| Alex Smith | 49 | 254 | 1 | 5.2 |
| De'Anthony Thomas | 14 | 113 | 1 | 8.1 |
| Cyrus Gray | 8 | 31 | 1 | 3.9 |
| Chase Daniel | 4 | 15 | 0 | 3.8 |
| Anthony Sherman | 2 | 8 | 0 | 4.0 |
| Joe McKnight | 1 | 3 | 0 | 3.0 |
| Jason Avant | 1 | 1 | 0 | 1.0 |
| A.J. Jenkins | 2 | -2 | 0 | -1.0 |
Receiving
| Travis Kelce | 87 | 67 | 862 | 5 | 9.9 |
| Dwayne Bowe | 95 | 60 | 754 | 0 | 7.9 |
| Jason Avant | 62 | 34 | 353 | 1 | 5.7 |
| Jamaal Charles | 59 | 40 | 291 | 5 | 4.9 |
| Albert Wilson | 28 | 16 | 260 | 0 | 9.3 |
| Anthony Fasano | 36 | 25 | 226 | 4 | 6.3 |
| Donnie Avery | 26 | 15 | 176 | 0 | 6.8 |
| De'Anthony Thomas | 31 | 23 | 156 | 0 | 5.0 |
| Knile Davis | 25 | 16 | 147 | 1 | 5.9 |
| Junior Hemingway | 21 | 12 | 108 | 0 | 5.1 |
| A.J. Jenkins | 15 | 9 | 93 | 0 | 6.2 |
| Anthony Sherman | 14 | 10 | 71 | 1 | 5.1 |
| Joe McKnight | 7 | 6 | 64 | 2 | 9.1 |
| Frankie Hammond | 11 | 4 | 45 | 0 | 4.1 |
| Demetrius Harris | 5 | 3 | 20 | 0 | 4.0 |
Defense
| Josh Mauga | ILB | 97 | 76 | 0.5 | 0 | 3 | 0 |
| Ron Parker | FS | 92 | 82 | 1.0 | 1 | 12 | 1 |
| Justin Houston | OLB | 68 | 59 | 22.0 | 0 | 5 | 4 |
| Husain Abdullah | FS | 67 | 54 | 0.0 | 1 | 8 | 0 |
| Tamba Hali | OLB | 55 | 43 | 6.0 | 0 | 0 | 3 |
| Sean Smith | CB | 48 | 45 | 0.0 | 1 | 16 | 0 |
| James-Michael Johnson | LB | 46 | 37 | 0.0 | 0 | 1 | 1 |
| Dontari Poe | DT | 43 | 35 | 6.0 | 0 | 1 | 0 |
| Allen Bailey | DE | 37 | 23 | 5.0 | 0 | 2 | 0 |
| Kurt Coleman | S | 34 | 31 | 0.0 | 3 | 6 | 1 |
| Jaye Howard | DE | 34 | 22 | 1.0 | 0 | 1 | 0 |
| Eric Berry | DB | 33 | 28 | 0.0 | 0 | 2 | 0 |
| Chris Owens | DB | 33 | 27 | 0.5 | 0 | 4 | 0 |
| Jamell Fleming | CB | 25 | 23 | 0.0 | 0 | 3 | 0 |
| Phillip Gaines | CB | 20 | 20 | 0.0 | 0 | 4 | 0 |
| Marcus Cooper | DB | 20 | 20 | 0.0 | 0 | 3 | 0 |
| Vance Walker | DE | 18 | 13 | 2.0 | 0 | 0 | 0 |
| Joe Mays | LB | 17 | 13 | 0.0 | 0 | 0 | 0 |
| Josh Martin | LB | 15 | 11 | 0.5 | 0 | 0 | 0 |
| Anthony Sherman | FB | 13 | 13 | 0.0 | 0 | 0 | 2 |
| Kevin Vickerson | DT | 11 | 8 | 0.0 | 0 | 1 | 0 |
| Kelcie McCray | S | 10 | 8 | 0.0 | 0 | 0 | 0 |
| Dee Ford | DE | 8 | 4 | 1.5 | 0 | 1 | 0 |
| Frank Zombo | LB | 8 | 8 | 0.0 | 0 | 0 | 0 |
| Daniel Sorensen | DB | 7 | 6 | 0.0 | 0 | 0 | 0 |
| Junior Hemingway | WR | 5 | 5 | 0.0 | 0 | 0 | 0 |
| Cyrus Gray | RB | 4 | 3 | 0.0 | 0 | 0 | 0 |
| Jerry Franklin | LB | 4 | 4 | 0.0 | 0 | 0 | 0 |
| Derrick Johnson | LB | 4 | 4 | 0.0 | 0 | 0 | 0 |
| Ryan Harris | OT | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Albert Wilson | WR | 3 | 3 | 0.0 | 0 | 0 | 1 |
| Alex Smith | QB | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Donnie Avery | WR | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Jason Avant | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Anthony Fasano | TE | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Thomas Gafford | LS | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Dustin Colquitt | P | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Mike DeVito | DE | 1 | 0 | 0.0 | 0 | 1 | 0 |
| Mike McGlynn | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Jamaal Charles | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Rodney Hudson | C | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Joe McKnight | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Frankie Hammond | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Eric Fisher | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Charcandrick West | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Cairo Santos | K | 1 | 1 | 0.0 | 0 | 0 | 0 |