Franchise 58 seasons 473–417–7 all-time 23 playoff trips 3 Super Bowls
2015 players
Passing
| Alex Smith | 470 | 307 | 3,486 | 20 | 7 | 7.4 |
| Chase Daniel | 2 | 2 | 4 | 0 | 0 | 2.0 |
| Cairo Santos | 1 | 1 | 3 | 0 | 0 | 3.0 |
Rushing
| Charcandrick West | 160 | 634 | 4 | 4.0 |
| Alex Smith | 84 | 498 | 2 | 5.9 |
| Spencer Ware | 72 | 403 | 6 | 5.6 |
| Jamaal Charles | 71 | 364 | 4 | 5.1 |
| Knile Davis | 28 | 72 | 1 | 2.6 |
| De'Anthony Thomas | 9 | 34 | 1 | 3.8 |
| Albert Wilson | 5 | 26 | 0 | 5.2 |
| Jeremy Maclin | 3 | 14 | 0 | 4.7 |
| Dontari Poe | 1 | 1 | 1 | 1.0 |
| Anthony Sherman | 1 | 0 | 0 | 0.0 |
| Chase Daniel | 2 | -2 | 0 | -1.0 |
Receiving
| Jeremy Maclin | 124 | 87 | 1,088 | 8 | 8.8 |
| Travis Kelce | 103 | 72 | 875 | 5 | 8.5 |
| Albert Wilson | 57 | 35 | 451 | 2 | 7.9 |
| Charcandrick West | 34 | 20 | 214 | 1 | 6.3 |
| Chris Conley | 31 | 17 | 199 | 1 | 6.4 |
| Jamaal Charles | 30 | 21 | 177 | 1 | 5.9 |
| De'Anthony Thomas | 24 | 17 | 140 | 1 | 5.8 |
| Jason Avant | 24 | 15 | 119 | 0 | 5.0 |
| James O'Shaughnessy | 9 | 6 | 87 | 0 | 9.7 |
| Demetrius Harris | 11 | 7 | 74 | 1 | 6.7 |
| Anthony Sherman | 5 | 4 | 34 | 0 | 6.8 |
| Knile Davis | 3 | 2 | 24 | 0 | 8.0 |
| Brian Parker | 2 | 1 | 6 | 0 | 3.0 |
| Spencer Ware | 6 | 6 | 5 | 0 | 0.8 |
Defense
| Derrick Johnson | LB | 108 | 87 | 4.0 | 2 | 8 | 2 |
| Ron Parker | FS | 77 | 66 | 5.0 | 3 | 12 | 1 |
| Marcus Peters | CB | 60 | 53 | 0.0 | 8 | 26 | 1 |
| Josh Mauga | ILB | 58 | 46 | 1.0 | 2 | 3 | 0 |
| Eric Berry | DB | 58 | 52 | 0.0 | 2 | 10 | 0 |
| Jaye Howard | DE | 55 | 34 | 5.5 | 0 | 0 | 1 |
| Tamba Hali | OLB | 47 | 38 | 6.5 | 0 | 1 | 2 |
| Sean Smith | CB | 45 | 40 | 0.0 | 2 | 12 | 0 |
| Tyvon Branch | S | 41 | 33 | 1.0 | 1 | 5 | 0 |
| Allen Bailey | DE | 36 | 24 | 4.5 | 0 | 0 | 2 |
| Dontari Poe | DT | 36 | 26 | 1.0 | 0 | 0 | 1 |
| Justin Houston | OLB | 28 | 23 | 7.5 | 2 | 6 | 1 |
| Husain Abdullah | FS | 27 | 22 | 0.0 | 0 | 1 | 0 |
| Daniel Sorensen | DB | 23 | 20 | 1.0 | 0 | 2 | 0 |
| Dee Ford | DE | 21 | 19 | 4.0 | 0 | 2 | 0 |
| Jamell Fleming | CB | 20 | 18 | 0.0 | 0 | 5 | 0 |
| Frank Zombo | LB | 19 | 16 | 3.0 | 0 | 0 | 1 |
| Mike DeVito | DE | 18 | 12 | 3.0 | 0 | 0 | 0 |
| Ramik Wilson | ILB | 18 | 11 | 0.0 | 0 | 0 | 0 |
| D.J. Alexander | LB | 13 | 12 | 0.0 | 0 | 0 | 0 |
| Steven Nelson | CB | 8 | 8 | 0.0 | 0 | 0 | 0 |
| Nick Williams | DT | 8 | 4 | 0.0 | 0 | 0 | 0 |
| Dezman Moses | LB | 6 | 5 | 0.0 | 0 | 0 | 1 |
| Anthony Sherman | FB | 6 | 5 | 0.0 | 0 | 0 | 0 |
| Phillip Gaines | CB | 6 | 5 | 0.0 | 0 | 0 | 0 |
| Chris Conley | WR | 4 | 4 | 0.0 | 0 | 0 | 0 |
| Rakeem Nunez-Roches | DT | 4 | 4 | 0.0 | 0 | 0 | 0 |
| Spencer Ware | RB | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Jeremy Maclin | WR | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Charcandrick West | RB | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Demetrius Harris | TE | 3 | 1 | 0.0 | 0 | 0 | 0 |
| Alex Smith | QB | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Albert Wilson | WR | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Marcus Cooper | DB | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Ben Grubbs | G | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Jamaal Charles | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Jah Reid | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Frankie Hammond | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Cairo Santos | K | 1 | 1 | 0.0 | 0 | 0 | 0 |
| James O'Shaughnessy | TE | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Mitch Morse | C | 1 | 1 | 0.0 | 0 | 0 | 0 |