Franchise 77 seasons 591–549–15 all-time 32 playoff trips 2 Super Bowls
2021 players
Passing
| Matthew Stafford | 601 | 404 | 4,886 | 41 | 17 | 8.1 |
| John Wolford | 4 | 1 | 5 | 0 | 1 | 1.2 |
| Johnny Hekker | 1 | 1 | 2 | 0 | 0 | 2.0 |
| Cooper Kupp | 1 | 0 | 0 | 0 | 0 | 0.0 |
Rushing
| Sony Michel | 208 | 845 | 4 | 4.1 |
| Darrell Henderson | 149 | 688 | 5 | 4.6 |
| Robert Woods | 8 | 46 | 1 | 5.8 |
| Matthew Stafford | 32 | 43 | 0 | 1.3 |
| Van Jefferson | 2 | 20 | 0 | 10.0 |
| Cooper Kupp | 4 | 18 | 0 | 4.5 |
| Odell Beckham Jr. | 2 | 14 | 0 | 7.0 |
| Buddy Howell | 5 | 11 | 0 | 2.2 |
| Jake Funk | 2 | 5 | 0 | 2.5 |
| Cam Akers | 5 | 3 | 0 | 0.6 |
| Johnny Hekker | 1 | 0 | 0 | 0.0 |
| John Wolford | 2 | -1 | 0 | -0.5 |
Receiving
| Cooper Kupp | 191 | 145 | 1,947 | 16 | 10.2 |
| Van Jefferson | 89 | 50 | 802 | 6 | 9.0 |
| Tyler Higbee | 85 | 61 | 560 | 5 | 6.6 |
| Robert Woods | 69 | 45 | 556 | 4 | 8.1 |
| Odell Beckham Jr. | 82 | 44 | 537 | 5 | 6.5 |
| Darrell Henderson | 40 | 29 | 176 | 3 | 4.4 |
| Ben Skowronek | 20 | 11 | 133 | 0 | 6.6 |
| Sony Michel | 33 | 21 | 128 | 1 | 3.9 |
| Kendall Blanton | 7 | 4 | 37 | 0 | 5.3 |
| Cam Akers | 3 | 3 | 10 | 0 | 3.3 |
| Johnny Mundt | 1 | 1 | 9 | 0 | 9.0 |
| Brycen Hopkins | 1 | 1 | 9 | 0 | 9.0 |