Franchise 57 seasons 427–465–5 all-time 17 playoff trips 0 Super Bowls
2020 players
Passing
| Justin Herbert | 595 | 396 | 4,336 | 31 | 10 | 7.3 |
| Tyrod Taylor | 30 | 16 | 208 | 0 | 0 | 6.9 |
| Easton Stick | 1 | 1 | 4 | 0 | 0 | 4.0 |
| Keenan Allen | 1 | 0 | 0 | 0 | 0 | 0.0 |
Rushing
| Austin Ekeler | 116 | 530 | 1 | 4.6 |
| Joshua Kelley | 111 | 354 | 2 | 3.2 |
| Kalen Ballage | 91 | 303 | 3 | 3.3 |
| Justin Jackson | 59 | 270 | 0 | 4.6 |
| Justin Herbert | 55 | 234 | 5 | 4.3 |
| Troymaine Pope | 15 | 76 | 0 | 5.1 |
| Joe Reed | 5 | 29 | 1 | 5.8 |
| Tyron Johnson | 3 | 17 | 0 | 5.7 |
| Gabe Nabers | 2 | 7 | 0 | 3.5 |
| Tyrod Taylor | 6 | 7 | 0 | 1.2 |
| Mike Williams | 1 | 1 | 0 | 1.0 |
| Jalen Guyton | 2 | 0 | 0 | 0.0 |
| Keenan Allen | 1 | -1 | 0 | -1.0 |
| Easton Stick | 1 | -2 | 0 | -2.0 |
| Ty Long | 1 | -28 | 0 | -28.0 |
Receiving
| Keenan Allen | 147 | 100 | 992 | 8 | 6.7 |
| Mike Williams | 85 | 48 | 756 | 5 | 8.9 |
| Hunter Henry | 93 | 60 | 613 | 4 | 6.6 |
| Jalen Guyton | 55 | 28 | 511 | 3 | 9.3 |
| Austin Ekeler | 65 | 54 | 403 | 2 | 6.2 |
| Tyron Johnson | 26 | 20 | 398 | 3 | 15.3 |
| Justin Jackson | 24 | 19 | 173 | 0 | 7.2 |
| Kalen Ballage | 37 | 29 | 166 | 0 | 4.5 |
| Donald Parham | 20 | 10 | 159 | 3 | 8.0 |
| Joshua Kelley | 23 | 23 | 148 | 0 | 6.4 |
| Stephen Anderson | 11 | 8 | 106 | 0 | 9.6 |
| K.J. Hill | 11 | 7 | 73 | 0 | 6.6 |
| Virgil Green | 6 | 3 | 50 | 1 | 8.3 |
| Troymaine Pope | 10 | 8 | 42 | 0 | 4.2 |
| Gabe Nabers | 7 | 5 | 25 | 2 | 3.6 |
Defense
| Kenneth Murray, Jr. | LB | 101 | 62 | 1.0 | 0 | 3 | 0 |
| Rayshawn Jenkins | SAF | 83 | 57 | 1.0 | 2 | 4 | 0 |
| Kyzir White | OLB | 72 | 45 | 0.5 | 0 | 3 | 0 |
| Nasir Adderley | FS | 67 | 56 | 0.0 | 1 | 3 | 0 |
| Michael Davis | CB | 62 | 46 | 0.0 | 3 | 14 | 0 |
| Linval Joseph | DT | 59 | 30 | 0.0 | 0 | 0 | 0 |
| Nick Vigil | OLB | 48 | 27 | 2.0 | 0 | 1 | 1 |
| Denzel Perryman | MLB | 47 | 24 | 1.0 | 0 | 1 | 1 |
| Casey Hayward | CB | 41 | 36 | 0.0 | 1 | 8 | 0 |
| Chris Harris | CB | 37 | 25 | 0.5 | 1 | 2 | 0 |
| Joey Bosa | DE | 34 | 24 | 7.5 | 0 | 1 | 0 |
| Uchenna Nwosu | LB | 32 | 19 | 4.5 | 0 | 2 | 0 |
| Justin Jones | DT | 29 | 14 | 1.0 | 0 | 0 | 0 |
| Jerry Tillery | DT | 29 | 18 | 3.0 | 0 | 2 | 2 |
| Isaac Rochell | DE | 26 | 14 | 2.5 | 0 | 1 | 0 |
| Tevaughn Campbell | DB | 22 | 16 | 0.0 | 1 | 3 | 1 |
| Jahleel Addae | S | 20 | 12 | 0.5 | 1 | 2 | 0 |
| Damion Square | DT | 19 | 8 | 1.0 | 0 | 0 | 0 |
| Brandon Facyson | DB | 16 | 13 | 0.0 | 0 | 0 | 1 |
| Melvin Ingram | LB | 9 | 4 | 0.0 | 1 | 2 | 0 |
| Jaylen Watkins | FS | 8 | 8 | 0.0 | 0 | 0 | 0 |
| Emeke Egbule | LB | 7 | 4 | 0.0 | 0 | 0 | 0 |
| Alohi Gilman | SAF | 7 | 5 | 0.0 | 0 | 0 | 0 |
| B.J. Bello | LB | 7 | 5 | 0.0 | 0 | 0 | 0 |
| Gabe Nabers | FB | 5 | 3 | 0.0 | 0 | 0 | 0 |
| Malik Jefferson | LB | 5 | 3 | 0.0 | 0 | 0 | 0 |
| Stephen Anderson | TE | 5 | 3 | 0.0 | 0 | 0 | 0 |
| Cole Mazza | LS | 4 | 1 | 0.0 | 0 | 0 | 0 |
| Cortez Broughton | DT | 4 | 0 | 0.0 | 0 | 1 | 0 |
| Ty Long | P | 4 | 3 | 0.0 | 0 | 0 | 0 |
| Joe Reed | WR | 3 | 1 | 0.0 | 0 | 0 | 0 |
| Justin Herbert | QB | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Jalen Guyton | WR | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Justin Jackson | RB | 3 | 1 | 0.0 | 0 | 0 | 0 |
| Jessie Lemonier | LB | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Cole Christiansen | LB | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Virgil Green | TE | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Ryan Groy | G | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Keenan Allen | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Mike Williams | WR | 1 | 1 | 0.0 | 1 | 1 | 0 |
| Austin Ekeler | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Hunter Henry | TE | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Drue Tranquill | LB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Tyron Johnson | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Joe Gaziano | DE | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Joshua Kelley | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |