Franchise 57 seasons 427–465–5 all-time 17 playoff trips 0 Super Bowls
2021 players
Passing
| Justin Herbert | 672 | 443 | 5,014 | 38 | 15 | 7.5 |
| Keenan Allen | 1 | 0 | 0 | 0 | 0 | 0.0 |
| Ty Long | 1 | 0 | 0 | 0 | 0 | 0.0 |
Rushing
| Austin Ekeler | 206 | 911 | 12 | 4.4 |
| Justin Jackson | 68 | 364 | 2 | 5.4 |
| Justin Herbert | 63 | 302 | 3 | 4.8 |
| Joshua Kelley | 33 | 102 | 0 | 3.1 |
| Larry Rountree III | 36 | 87 | 1 | 2.4 |
| Jalen Guyton | 7 | 34 | 0 | 4.9 |
| Andre Roberts | 3 | 19 | 0 | 6.3 |
| Gabe Nabers | 3 | 8 | 0 | 2.7 |
| Josh Palmer | 1 | 6 | 0 | 6.0 |
| Maurice Ffrench | 1 | 3 | 0 | 3.0 |
| Chase Daniel | 2 | -2 | 0 | -1.0 |
Receiving
| Mike Williams | 129 | 76 | 1,146 | 9 | 8.9 |
| Keenan Allen | 157 | 106 | 1,138 | 6 | 7.2 |
| Austin Ekeler | 94 | 70 | 647 | 8 | 6.9 |
| Jared Cook | 83 | 48 | 564 | 4 | 6.8 |
| Jalen Guyton | 48 | 31 | 448 | 3 | 9.3 |
| Josh Palmer | 49 | 33 | 353 | 4 | 7.2 |
| Donald Parham | 27 | 20 | 190 | 3 | 7.0 |
| Justin Jackson | 25 | 22 | 178 | 0 | 7.1 |
| Stephen Anderson | 19 | 16 | 165 | 1 | 8.7 |
| Jason Moore | 4 | 3 | 56 | 0 | 14.0 |
| Tre' McKitty | 8 | 6 | 45 | 0 | 5.6 |
| Joshua Kelley | 6 | 5 | 38 | 0 | 6.3 |
| Andre Roberts | 2 | 1 | 35 | 0 | 17.5 |
| K.J. Hill | 3 | 3 | 30 | 0 | 10.0 |
| Gabe Nabers | 3 | 3 | 17 | 0 | 5.7 |
| Larry Rountree III | 2 | 1 | -1 | 0 | -0.5 |