Franchise 57 seasons 427–465–5 all-time 17 playoff trips 0 Super Bowls
2022 players
Passing
| Justin Herbert | 699 | 477 | 4,739 | 25 | 10 | 6.8 |
| Chase Daniel | 12 | 8 | 52 | 1 | 0 | 4.3 |
Rushing
| Austin Ekeler | 204 | 915 | 13 | 4.5 |
| Joshua Kelley | 69 | 287 | 2 | 4.2 |
| Justin Herbert | 54 | 147 | 0 | 2.7 |
| Sony Michel | 36 | 106 | 0 | 2.9 |
| Isaiah Spiller | 18 | 41 | 0 | 2.3 |
| Larry Rountree III | 13 | 19 | 0 | 1.5 |
| Keenan Allen | 1 | 8 | 0 | 8.0 |
| Zander Horvath | 4 | 8 | 0 | 2.0 |
| Josh Palmer | 1 | 4 | 0 | 4.0 |
| Chase Daniel | 1 | 4 | 0 | 4.0 |
| Gerald Everett | 1 | 0 | 0 | 0.0 |
| DeAndre Carter | 2 | -15 | 0 | -7.5 |
Receiving
| Mike Williams | 93 | 63 | 895 | 4 | 9.6 |
| Josh Palmer | 107 | 72 | 769 | 3 | 7.2 |
| Keenan Allen | 89 | 66 | 752 | 4 | 8.4 |
| Austin Ekeler | 127 | 107 | 722 | 5 | 5.7 |
| Gerald Everett | 87 | 58 | 555 | 4 | 6.4 |
| DeAndre Carter | 65 | 46 | 538 | 3 | 8.3 |
| Donald Parham | 12 | 10 | 130 | 1 | 10.8 |
| Joshua Kelley | 25 | 14 | 101 | 0 | 4.0 |
| Michael Bandy | 21 | 10 | 89 | 0 | 4.2 |
| Tre' McKitty | 18 | 10 | 72 | 0 | 4.0 |
| Jalen Guyton | 4 | 2 | 64 | 0 | 16.0 |
| Sony Michel | 13 | 9 | 53 | 0 | 4.1 |
| Stone Smartt | 5 | 4 | 17 | 0 | 3.4 |
| Larry Rountree III | 2 | 2 | 14 | 0 | 7.0 |
| Isaiah Spiller | 3 | 3 | 13 | 0 | 4.3 |
| Zander Horvath | 8 | 5 | 8 | 2 | 1.0 |
| Jason Moore | 2 | 1 | 5 | 0 | 2.5 |
| Richard Rodgers | 4 | 1 | 4 | 0 | 1.0 |
| Justin Herbert | 2 | 2 | -10 | 0 | -5.0 |