Franchise 57 seasons 427–465–5 all-time 17 playoff trips 0 Super Bowls
2023 players
Passing
| Justin Herbert | 456 | 297 | 3,134 | 20 | 7 | 6.9 |
| Easton Stick | 174 | 111 | 1,129 | 3 | 1 | 6.5 |
| Keenan Allen | 2 | 1 | 49 | 1 | 0 | 24.5 |
Rushing
| Austin Ekeler | 179 | 628 | 5 | 3.5 |
| Joshua Kelley | 107 | 405 | 2 | 3.8 |
| Justin Herbert | 52 | 228 | 3 | 4.4 |
| Easton Stick | 27 | 144 | 1 | 5.3 |
| Derius Davis | 14 | 101 | 0 | 7.2 |
| Isaiah Spiller | 37 | 96 | 0 | 2.6 |
| Gerald Everett | 3 | 10 | 0 | 3.3 |
| Quentin Johnston | 3 | 9 | 0 | 3.0 |
| Keenan Allen | 2 | 6 | 0 | 3.0 |
| Elijah Dotson | 4 | 6 | 0 | 1.5 |
| Josh Palmer | 1 | 6 | 0 | 6.0 |
| Mike Williams | 1 | 3 | 0 | 3.0 |
| Nick Niemann | 1 | 0 | 0 | 0.0 |
Receiving
| Keenan Allen | 150 | 108 | 1,243 | 7 | 8.3 |
| Josh Palmer | 61 | 38 | 581 | 2 | 9.5 |
| Austin Ekeler | 74 | 51 | 436 | 1 | 5.9 |
| Quentin Johnston | 67 | 38 | 431 | 2 | 6.4 |
| Gerald Everett | 70 | 51 | 411 | 3 | 5.9 |
| Donald Parham | 41 | 27 | 285 | 4 | 7.0 |
| Mike Williams | 26 | 19 | 249 | 1 | 9.6 |
| Alex Erickson | 29 | 16 | 232 | 1 | 8.0 |
| Stone Smartt | 21 | 11 | 155 | 1 | 7.4 |
| Jalen Guyton | 21 | 10 | 89 | 1 | 4.2 |
| Derius Davis | 17 | 15 | 66 | 0 | 3.9 |
| Isaiah Spiller | 6 | 6 | 34 | 0 | 5.7 |
| Keelan Doss | 13 | 6 | 33 | 0 | 2.5 |
| Joshua Kelley | 12 | 8 | 32 | 0 | 2.7 |
| Elijah Dotson | 2 | 2 | 13 | 0 | 6.5 |
| Justin Herbert | 1 | 1 | 10 | 0 | 10.0 |
| Simi Fehoko | 2 | 1 | 9 | 1 | 4.5 |
| Nick Vannett | 1 | 1 | 3 | 0 | 3.0 |
Defense
| Derwin James | FS | 115 | 76 | 2.0 | 1 | 7 | 0 |
| Eric Kendricks | MLB | 105 | 67 | 3.5 | 0 | 6 | 1 |
| Kenneth Murray, Jr. | LB | 96 | 68 | 3.0 | 1 | 4 | 0 |
| Alohi Gilman | SAF | 64 | 40 | 0.0 | 2 | 10 | 3 |
| Khalil Mack | OLB | 62 | 45 | 17.0 | 0 | 10 | 5 |
| Asante Samuel Jr. | CB | 58 | 51 | 0.0 | 2 | 13 | 0 |
| Michael Davis | CB | 57 | 47 | 0.0 | 1 | 10 | 0 |
| Tuli Tuipulotu | LB | 44 | 28 | 4.5 | 0 | 1 | 2 |
| Nick Niemann | LB | 38 | 20 | 0.0 | 0 | 1 | 0 |
| Austin Johnson | NT | 38 | 16 | 0.0 | 0 | 2 | 1 |
| Dean Marlowe | S | 37 | 29 | 1.0 | 0 | 0 | 0 |
| Ja'Sir Taylor | CB | 30 | 23 | 0.0 | 1 | 8 | 0 |
| Nick Williams | DT | 29 | 13 | 1.0 | 0 | 0 | 0 |
| Deane Leonard | CB | 28 | 22 | 0.0 | 0 | 3 | 1 |
| Essang Bassey | DB | 21 | 13 | 0.0 | 0 | 3 | 0 |
| Otito Ogbonnia | DT | 18 | 7 | 0.0 | 0 | 0 | 0 |
| Joey Bosa | DE | 17 | 11 | 6.5 | 0 | 1 | 1 |
| Daiyan Henley | LB | 15 | 8 | 0.0 | 0 | 0 | 0 |
| Justin Hollins | LB | 14 | 8 | 1.0 | 0 | 0 | 0 |
| Jaylinn Hawkins | SAF | 14 | 6 | 0.0 | 0 | 1 | 0 |
| Scott Matlock | DT | 14 | 5 | 0.0 | 0 | 0 | 0 |
| Morgan Fox | DE | 11 | 7 | 5.5 | 0 | 0 | 0 |
| Christopher Hinton | DT | 8 | 2 | 0.0 | 0 | 0 | 0 |
| Josh Harris | LS | 5 | 3 | 0.0 | 0 | 0 | 0 |
| Raheem Layne | SAF | 5 | 3 | 0.0 | 0 | 0 | 0 |
| Blake Lynch | LB | 4 | 3 | 0.0 | 0 | 0 | 0 |
| Amen Ogbongbemiga | LB | 3 | 1 | 0.0 | 0 | 0 | 0 |
| Andrew Farmer | LB | 3 | 1 | 0.0 | 0 | 0 | 0 |
| AJ Finley | SAF | 3 | 1 | 0.0 | 0 | 0 | 1 |
| JT Woods | SAF | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Chris Rumph II | DE | 3 | 2 | 0.0 | 0 | 0 | 0 |
| Rashawn Slater | OT | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Stephen Anderson | TE | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Will Clapp | C | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Simi Fehoko | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Tanner Muse | LB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Austin Ekeler | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Trey Pipkins | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Donald Parham | TE | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Cameron Dicker | K | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Josh Palmer | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Quentin Johnston | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |