Franchise 57 seasons 427–465–5 all-time 17 playoff trips 0 Super Bowls
2025 players
Passing
| Justin Herbert | 512 | 340 | 3,727 | 26 | 13 | 7.3 |
| Trey Lance | 57 | 27 | 226 | 0 | 1 | 4.0 |
Rushing
| Kimani Vidal | 155 | 643 | 3 | 4.1 |
| Omarion Hampton | 124 | 545 | 4 | 4.4 |
| Justin Herbert | 83 | 498 | 2 | 6.0 |
| Jaret Patterson | 41 | 159 | 1 | 3.9 |
| Trey Lance | 17 | 85 | 0 | 5.0 |
| Najee Harris | 15 | 61 | 0 | 4.1 |
| Hassan Haskins | 17 | 47 | 0 | 2.8 |
| Tre Harris | 2 | 10 | 0 | 5.0 |
| Amar Johnson | 2 | 8 | 0 | 4.0 |
| Quentin Johnston | 2 | 7 | 0 | 3.5 |
| Derius Davis | 2 | 5 | 0 | 2.5 |
| Tyler Conklin | 1 | 2 | 0 | 2.0 |
Receiving
| Ladd McConkey | 106 | 66 | 789 | 6 | 7.4 |
| Keenan Allen | 122 | 81 | 777 | 4 | 6.4 |
| Quentin Johnston | 84 | 51 | 735 | 8 | 8.8 |
| Oronde Gadsden II | 69 | 49 | 664 | 3 | 9.6 |
| Tre Harris | 43 | 30 | 324 | 1 | 7.5 |
| Omarion Hampton | 35 | 32 | 192 | 1 | 5.5 |
| Kimani Vidal | 22 | 16 | 136 | 1 | 6.2 |
| Tyler Conklin | 10 | 7 | 101 | 0 | 10.1 |
| Will Dissly | 16 | 11 | 97 | 0 | 6.1 |
| KeAndre Lambert-Smith | 12 | 5 | 51 | 1 | 4.2 |
| Najee Harris | 3 | 3 | 25 | 0 | 8.3 |
| Tucker Fisk | 4 | 2 | 19 | 0 | 4.8 |
| Hassan Haskins | 4 | 4 | 13 | 0 | 3.2 |
| Scott Matlock | 4 | 4 | 12 | 1 | 3.0 |
| Derius Davis | 3 | 2 | 10 | 0 | 3.3 |
| Jaret Patterson | 4 | 3 | 8 | 0 | 2.0 |
Defense
| Daiyan Henley | LB | 101 | 52 | 3.5 | 2 | 5 | 0 |
| Derwin James | FS | 93 | 49 | 2.0 | 3 | 7 | 1 |
| Tony Jefferson | S | 56 | 36 | 0.0 | 4 | 7 | 0 |
| Troy Dye | LB | 56 | 26 | 1.0 | 0 | 4 | 1 |
| Tarheeb Still | CB | 52 | 36 | 0.0 | 0 | 7 | 0 |
| Elijah Molden | CB | 51 | 27 | 0.0 | 1 | 1 | 0 |
| Cam Hart | CB | 48 | 37 | 0.0 | 1 | 11 | 0 |
| Tuli Tuipulotu | LB | 46 | 32 | 13.0 | 0 | 3 | 2 |
| Denzel Perryman | MLB | 44 | 27 | 0.0 | 0 | 3 | 0 |
| Justin Eboigbe | DT | 39 | 27 | 6.0 | 0 | 0 | 0 |
| Odafe Oweh | LB | 38 | 20 | 7.5 | 0 | 0 | 0 |
| Benjamin St-Juste | CB | 37 | 22 | 0.0 | 1 | 7 | 0 |
| Del'Shawn Phillips | LB | 37 | 16 | 1.0 | 0 | 0 | 0 |
| Khalil Mack | OLB | 32 | 19 | 5.5 | 0 | 0 | 4 |
| Teair Tart | DT | 32 | 22 | 0.0 | 0 | 4 | 1 |
| Jamaree Caldwell | DT | 30 | 13 | 1.0 | 0 | 1 | 1 |
| R.J. Mickens | SAF | 29 | 18 | 0.0 | 2 | 2 | 0 |
| Da'Shawn Hand | DE | 27 | 16 | 1.5 | 1 | 4 | 0 |
| Donte Jackson | CB | 24 | 16 | 0.0 | 4 | 12 | 0 |
| Marlowe Wax | LB | 21 | 11 | 0.0 | 0 | 0 | 0 |
| Bud Dupree | OLB | 16 | 9 | 2.0 | 0 | 1 | 0 |
| Kendall Williamson | SAF | 14 | 8 | 0.0 | 0 | 0 | 0 |
| Hassan Haskins | RB | 11 | 5 | 0.0 | 0 | 0 | 0 |
| Marcus Williams | FS | 10 | 7 | 0.0 | 0 | 0 | 0 |
| Otito Ogbonnia | DT | 10 | 7 | 0.5 | 0 | 0 | 0 |
| Marcus Maye | FS | 5 | 1 | 0.0 | 0 | 0 | 0 |
| Deane Leonard | CB | 5 | 2 | 0.0 | 0 | 0 | 0 |
| Cameron Dicker | K | 4 | 2 | 0.0 | 0 | 0 | 0 |
| Keenan Allen | WR | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Kimani Vidal | RB | 3 | 2 | 0.0 | 0 | 0 | 0 |
| Nikko Reed | DB | 2 | 1 | 0.0 | 0 | 1 | 0 |
| Kyle Kennard | LB | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Justin Herbert | QB | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Josh Harris | LS | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Austin Deculus | OT | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Quentin Johnston | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Ladd McConkey | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Oronde Gadsden II | TE | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Omarion Hampton | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |